Clinical and Translational Science Awards CTSAs: Building Connections

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National Center forResearch Resources
A c c e l e r a t i n g a n d e n h a n c i
n g r e s e a r c h f r o m b a s i c d i
s c o v e r y t o i m p r o v e d p a t I e
n t c a r e
NATIONAL INSTITUTES OF HEALTH
Clinical and Translational Science Awards
(CTSAs) Building Connections February 4,
2009 National Advisory Council on Drug Abuse
Barbara Alving, MD, MACP Director National Center
for Research Resources
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National Center for Research Resources
Accelerating research from basic discovery to
improved patient care
Animalmodel resources
community engagement
Improved patient care
Pre-clinical
Community
imaging informatics advances
Clinicalresearch support
Clinical
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Impetus for the CTSA Program
To ensure new discoveries lead to improved public
health, clinical science must evolve to better

• Implement biomedical discoveries
• Develop, test, and bring new prevention
  strategies into medical practice more rapidly
• Catalyze change - lower barriers between
  disciplines
• Encourage creative and innovative approaches

CTSAWeb.org
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CTSAs Building a National Consortiumof
Academic Health Centers
Currently 38 CTSAs Sites Across the Country
CT
Participating Institutions
Members 2006 2007
New Members 2008
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CTSA Providing Local Leveraging Opportunities
Atlanta Clinical and Translational Science
Institute (Atlanta-CTSI) at Emory University
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CTSA Creating National Partnership
Opportunities Consortium Governance
Advisory providing guidance and input to the
NCRR Director Oversight identifying and
selecting collaborative opportunities to
facilitate research, coordinating Consortium-wide
approaches to research, and overseeing
topic-specific efforts across the
Consortium Steering coordinating institutional
topic-specific efforts with the national CTSA
Consortium each Steering Committee has an
Operations subgroup that takes timely action on
emergent topic issues
www.ctsaweb.org
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CTSA National Strategic Plan Priorities

• Goal One
• Enhancing National Clinical and Translational
  Research Capability
• Clinical research management
• Research infrastructure
• Phenotyping human and preclinical models
• Goal Two
• Enhancing Training and Career Development of
  Clinical and Translational Investigators
• Goal Three
• Enhancing Consortium-Wide Collaborations
• Social networking
• Inventory of resources
• Data sharing
• Goal Four
• Enhancing the Health of Our Communities and the
  Nation
• Community engagement
• Public health policy

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CTSA Creating National Partnership Opportunities
Working as a Consortium, we have established a
committee structure to execute the
vision and goals of the CTSA program
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CTSAweb.org

• Resources for Researchers
• Building Connections
• e-Newsletter
• Communication Toolkit

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CTSA Creating Regional Partnership
Opportunities
Mayo Clinic College of Medicine
Universityof Iowa
University of Washington
University of Chicago
University of Wisconsin
Oregon Health Science University
University of Rochester
Yale University
University of California, Davis
Weill Cornell Medical College
Columbia University
University of California, San Francisco
Rockefeller University
Albert Einstein College of Medicine
Stanford University
The Scripps Research Institute
Washington University in St. Louis
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Encouraging and Enhancing Collaboration
CTSA Consortium Informatics Pilots
Clinical and Translational Information Exchange
Environment Informatics Pilots

• Implementation and development of tools for
  clinical investigators to facilitate small and
  medium sized research studies
• Enhance the collection and management of data in
  small and medium sized studies
• Requirements
• At least three CTSA must collaborate
• Data and software sharing
• Must incorporate institutional database support
  that is flexible, secure, and easily accessible
  on demand

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Informatics Pilot Projects

• PhysioMIMI at Case Western Reserve University
• Includes investigators from Marshfield Clinic,
  University of Wisconsin and University of
  Michigan
• Collects, manages, and analyzes diverse data
  types across institutions
• Allows secure, safe and regulated transfer of
  information from clinical care systems and
  research databases
• Sharing Clinical Data at University of Washington
  
• Includes investigators from University of
  California, San Francisco, University of
  California, Davis
• Allow researchers to access large shared datasets
• Assist with designing research studies and
  generating hypotheses
• Research Electronic Data Capture (REDCap) at
  Vanderbilt
• Includes investigators from Oregon Health and
  Sciences University and Mayo Clinic
• Provide an easy way for researchers to develop a
  secure, web-based application for collecting,
  managing and sharing of their clinical and
  translational research data
• Create secure and flexible interoperability
  between REDCap and external data systems thus
  ensuring data quality in information exchange

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Informatics Pilots
University of Washington
WA
ME
MT
ND
Mansfield Clinic University of
Wisconsin Madison
Oregon Health Science University
VT
OR
MN
NH
WI
ID
NY
MA
SD
CT
University of Michigan
Mayo Clinic College of Medicine
WY
MI
RI
NJ
PA
IA
University of California, Davis
NE
NV
OH
MD
IN
DE
IL
UT
Case Western Reserve University
CO
WV
University of California, San Francisco
KS
VA
CA
MO
KY
Vanderbilt University
NC
TN
OK
AZ
AR
SC
NM
GA
MS
AL
LA
TX
AK
FL
HI
PR
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CTSA Consortium Building Connections with
Business Schools
CTSA are partnering with business schools to

• Develop business plans, design, and implement
  community surveys
• Create innovative cross-educational programs
• Develop case studies to pilot programs
• Collaborate with international colleagues
• Prepare cost analyses
• Protect CTSA-developed patents
• Form industry partnership programs

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Encouraging and Enhancing Collaboration
NIH Opportunities
CTSA Thematic Research Networks/CTSA Interest
Groups

• Emergency Medicine
• Sleep Research Network
• Critical Care
• Neurology
• Neuroimaging

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Educational Impact of CTSA Program

• Doubled the clinical and translational training
  workforce from 2006 - 2008
• Increased the number of regional training
  interactions among consortium sites
• Awarded a supplement to develop a National CTSA
  Educational Resource Program (NCERP) that will
• Identify, catalog, and assess training modules in
  clinical and translational research
• Enhance and broaden training opportunities for
  clinician-scientists across the CTSA consortium

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Educational Impact of CTSA Program (Based on
2008 Annual Progress Reports from first 24 CTSAs)
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CTSA Consortium and NIDA Collaborations(Based on
2008 Annual Progress Reports from first 24 CTSAs)
NIDA Grants Utilizing CTSAs
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CTSA Consortium and NIDA Collaborations(Based on
2008 Annual Progress Reports from first 24 CTSAs)
NIDA Grants Utilizing CTSAs
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NIDA Clinical Trials Network
Clinical Trials Network (CTN)

• Established in 1999 to conduct research in a wide
  variety of community based treatment programs
  across the United States.
• Provides a unique opportunity to address a
  variety of underserved populations, and in
  particular to evaluate access to and
  effectiveness of treatments for ethnic
  minorities.
• Seeks to reduce barriers to all its studies and
  has attended carefully to recruitment and
  retention of women and ethnic minority groups.

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Opportunities for Partnership with CTSAs and NIDA
Clinical Trials Network
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Funding Opportunities at NIDA
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National Center for Research Resourceswww.ncrr.ni
h.gov

• Translating Research from Basic Discovery to
  Improved Patient Care