INNATE HOST DEFENSES

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INNATE HOST DEFENSES

• CHAPTER 16

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Host Defenses

• Adaptive
• Innate

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Defense Barriers

• Physical
• Chemical
• Cellular defenses

• Inflammation
• Fever
• Molecular defenses

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Physical Barriers

• Skin
• Mucous membranes

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Chemical Barriers

• Salt
• pH
• Lysozyme

• Transferin
• Lactoferrin
• Defensins

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Cellular Defenses - Granulocytes

• Basophils/Mast cells
• Eosinophils

• Neutrophils
• Dendritic cells

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Cellular Defenses Agranulocytes

• Monocytes

• Lymphocytes

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Blood Cells
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Phagocytosis

• Cells Involved
• Process
• Chemotaxis
• Adherence
• Ingestion
• Digestion

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Characteristics of Inflammation

• Acute Inflammation
• Repair/
• Regeneration
• Chronic Inflammation

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Fever

• Exogenous/Endogenous Pyrogens
• Benefits/Risks
• Leukocyte Endogenous Mediator

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Interferon

• Interferon protein

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Complement System
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Complement System
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Complement Cytolysis
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Complement Cytolysis
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Non-specific Defenses