PROJECT 8: THREE DIMENSIONAL IMAGING OF THE MOUSE

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PROJECT 8THREE DIMENSIONAL IMAGING OF THE MOUSE

• Fenster PhD,
• J. Lacefield PhD, D. Downey MD
• 4 Grad Students, 2 technicians, 1 programmer

Robarts Research Institute, London, CANADA
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PROJECT 8

• OBJECTIVE To develop and evaluate 3D UBM and CTM
  S/W systems for quantitative mouse imaging
• Based on 3D US development and 12 patents at RRI
• Extend to 3D visualization and quantification
  applications to mouse imaging
• Small budget

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TASKS

• Integrate 3D S/W with UBM CTM
• Develop multi-window platform
• Develop segmentation S/W
• Develop 3D multi-modality S/W registration
• Develop retrospective gating technique

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STATUS REPORT (1)

• Licensed 3D US acquisition and visualization
  patents to 3D Vet inc. for veterinary imaging at
  low frequencies
• Developed complete 3D US system for 3D Vet using
  veterinary commercial US system
• Demonstrated utility for veterinary use (Dogs,
  cats, elephant, horses)
• Discussions on next upgrade

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STATUS REPORT (2)

• Licensed 3D US acquisition and visualization
  patents to VisualSonics
• Licensing 3D segmentation patent to VisualSonics
• Helped to integrate and test 3D visualization S/W
  into VisualSonics UBM
• Developing robust semi-automated segmentation

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DEFORMABLE MODELS Structure Dynamics
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MOUSE PROSTATE TUMOURno editing
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MOUSE PROSTATE TUMOURwith editing
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RESULTS Manual vs. Algorithm Area(human
prostate at 10MHz)
Accuracy 95
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ORDCF FUNDED FUTURE WORK

• 3D segmentation with auto-correction (patent to
  be filed)
• Automated segmentation with auto-correction
  (patent to be filed)
• 3D multi-modality registration
• WORK WITH NON-ORDCF FUNDING
• Research applications in Oncology, Cardiology,
  MSK, developmental biology, stem-cell biology and
  robotics ongoing (J. Lacefield plus team)