Developing business from CSL science

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Developing business from CSL science

• Robert Bolton
• Commercial Director, CSL
• Board Member, Forsite Diagnostics Ltd

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Central Science Laboratory
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UK Public Sector Science and Engineering Funding
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Central Science Laboratory
Sustaining and Safeguarding Agriculture, Food
and Environment
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CSL Background

• Delivering sustainable land use, safe food and a
  healthy environment
• Formed in 1992, from staff across 17 sites and
  transferred to York by 1999
• Today 700 staff, over 600 live contracts with
  annual turnover - 50m
• Three-way focus National Laboratory, RD,
  Services and Advice
• Modern Laboratory complex on a secure site

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Central Science Laboratory

• Objective Delivering sustainable land use,
  safe food and a healthy environment.
• Role Science support for evidence-based
  policies, implementation of Regulations and
  provision of contingency capacity.
• Outlook National laboratory collaborating
  with equivalent laboratories globally forming
  alliances to strengthen competitive position.
• Capabilities Multi-disciplinary science
  base, world-class facilities and professional
  administration teams.
• Ownership model Part of Defra (Net Running
  Cost Agency) operated on efficient business lines
  within the public sector.

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Customers
Department for Environment Food and Rural Affairs
Pesticides Safety Directorate
European Commission
Veterinary Medicines Directorate
Overseas Governments
Department for International Development
Environment Agency
Countryside Agencies
Industry and Levy Boards
Food Standards Agency
New customers Home Office Research Councils
FCO MOD
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CSL Funding 2006/07
48 M
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CSL diagnostics developments

• Novel rapid nucleic acid purification and storage
  technology patent application
• Extensive expertise and know-how in the area of
  lab-based PCR analysis services, plus
  out-licensing arrangement
• Bacteriophage-based methods of bacterial
  detection extensive patent coverage, licensed
  to diagnostics company
• Extensive expertise and know-how in the area of
  design and use of microarrays for diagnostic
  purposes
• Lateral Flow Devices

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LFD Formats

• Sandwich assay
• Licence currently required
• Pathogen detection
• Traditional 2 line positive result

• Competitive assay
• No patent encumbrances
• Target molecule detection
• Desirable for semi- quantitation

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Development of competitive LFDs

• LFD assays for plant viruses, bacteria and fungal
  pathogens
• Extending range of targets, commercial funding
  and collaborations in all CSL Science groups
• Avian influenza
• Progesterone in milk
• SRM peptide targets
• Invertebrates (Bee Pathogens)
• Cortisol stress marker in saliva
• Mycotoxins
• Antibiotics
• Suitable for high detection limits

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Innovation Timeline

• 1996 The initial research
• 2000 Launch of Pocket Diagnostic Brand
• 2001 Winner of Westminster Medal

• 2002 Separate business unit
• 2004 Winner of Venturefest York
• 2006 Spin out Forsite Diagnostics Ltd
• 2007 External financing/sale

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Pocket Diagnostic

• Launched in 2000
• Current portfolio of 25 kits virus, bacteria,
  fungi
• Rapidly expanding product pipeline
• Focus on horticulture
• Focus on quality
• Worlds 1 On-site test kit
• US approval for brown rot
• Buying On-Line
• Strong brand identity

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Pocket Diagnostic Sales
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expanding business horizons through the power
of on-site diagnostics
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Markets
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developing rapid, cost-effective diagnostic
systems for field use and high throughput
laboratory applications