SIVD PPG Study Overview

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SIVD PPG Study Overview
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Study Design

• Methods
• Clinical Evaluation (Diagnosis)
• Neuropsychological Assessment
• Structural Neuroimaging (MRI)
• Functional Imaging (PET)
• Neuropathology

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Study Design

• Recruitment
• Stratification categories
• Cognitive status
• Normal - CDR 0.0
• MCI - CDR 0.5
• Demented - CDR 1.0
• Subcortical ischemic vascular disease
• Presence versus absence of lacunes
• Cortical stroke exclusionary (until recently)

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Study Design

• Longitudinal
• Rolling enrollment
• Differing numbers of assessments
• Clinical/Neuropsychological
• Yearly assessments
• MRI
• Normals - every 4 years
• MCI/Demented - every 2 years

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Variables

• Clinical diagnosis
• Normal - CDR 0.0
• MCI - CDR 0.5
• Demented - CDR 1.0

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Neuropsychological Test Battery

• MAS List Learning Test
• WMS-R Digit Span
• WMS-R Visual Span
• Biber Visual Learning Test
• Finger Tapping Test
• Token Test
• FAS Test

• Animal Category Fluency
• Boston Naming Test
• Benton Form Discrimination Test
• Mattis Dementia Rating Scale
• Stroop Test

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Neuropsychological Composite Measures

• Global
• MAS List Learning Trials 1 and 2
• Digit Span forward and backward
• Animal category fluency
• Letter fluency A

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Neuropsychological Composite Measures

• Memory
• MAS List Learning
• Trial 1 and 2 (supraspan)
• Trial 3
• Free recall
• Cued recall

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Neuropsychological Composite Measures

• Executive
• Digit Span and Visual Span backwards
• FAS - F, A, S
• Mattis Dementia Rating Scale
• Initiation-Perseveration subscale

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MRI Variables

• Segmented Volumes
• Cortical gray matter
• White matter hyperintensity
• Subcortical lacunes
• Hippocampus
• Total intracranial volume

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Continuous MRI measures ( intracranial volume)
Hippocampus
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Collaborators

• Helena Chui, M.D. - Project principal
  investigator
• University of Southern California
• UC Berkeley
• William Jagust, M.D.
• UC Davis
• Bruce Reed, Ph.D.
• Charles DeCarli, M.D.
• William Ellis, M.D.
• Danielle Harvey, Ph.D.
• Laurel Beckett, Ph.D.

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Collaborators

• USC-Rancho Los Amigos
• Helena Chui, M.D.
• Wendy Mack, Ph.D.
• Chris Zarow, Ph.D.
• UC San Francisco
• Michael Weiner, M.D.
• Joel Kramer, Ph.D.
• UCLA
• Harry Vinters, M.D.