Cerebral Metabolism Following Traumatic Brain Injury

1
Potential relationships between oxidative and
glucose metabolism following TBI
Molar Oxygen-to-Glucose Ratio (OGR) Normal 5.6
Post-TBI
O2
OGRgt5.6
OGRlt5.6
OGR5.6
O2
O2
OGRlt5.6
O2
O2
Glucose
Glucose
Glucose
Glucose
Glucose
Normal brain Normal OGR
Hyperglycolysis Low OGR
Metabolic Depression Normal OGR
High OGR
2
Lactate May Be Consumed In Human Brain Following
TBI Opportunity for Metabolic Therapy!
Using The Alternative Fuel ßHB Induces
Neuroprotection Following TBI
CMRlactate 0.18 mg/100g/min
0.5
95 confidence
CMRlactate
0
Normal controls
Patients N35 Control N16
-0.5
0 1 2 3 4 5
Post-injury day
3
Cerebral Metabolism Following TBIGeneral
Conclusions

• Rules have changed
• Fuel use is dictated by specific needs
• It is not the amount but perhaps the type of fuel
  available that is important
• Finally, it is never nice to fool mother nature

4
(No Transcript)