Gene arrangements

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(human chromosome 22)
(human chromosome 2)
(human chromosome 14)
Gene arrangements
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Kappa gene expression
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H-gene expression
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Recombination signal sequences
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Allelic exclusion (only in B and T cells)
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Model of allelic exclusion
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Class switching
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Secreted vs. membrane forms of IgM
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Secretory pathway
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The T-Cell Receptor

• Variations on a Theme by Molecules of the Ig
  Superfamily!

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Structural similarities between Ig and TCR.
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Germ-line organization of murine TCR genes.
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Gene Rearrangements
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Circular DNA isolated from thymocytes undergoing
TCR rearrangement
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Affinity constants and Roles of Co-receptors in
TCR binding.
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HIV buds out of cells.
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