Nincs diac

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ISEE/CEEC Meeting, Budapest,
Hungary, 911 June 2005
Association of lung cancer and mould in the flat
in an environmental epidemiological survey
Mihály János VARRÓ1, Mária POSGAY2, György
UNGVÁRY3, Zsolt LANG4 1National Institute of
Environmental Health, Fodor József National
Center for Public Health (NCPH),
Budapest 2National Institute of Occupational
Health, NCPH, Budapest 3NCPH, Budapest 4Nomogram
Ltd., Budapest
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ISEE/CEEC Meeting, Budapest,
Hungary, 911 June 2005
Introduction
A survey To evaluate the health impact of
environmental asbestos exposure Lung cancer
mould in the flat
Objective
To assess associations between mould in the
flat and lung cancer in an adult town population
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ISEE/CEEC Meeting, Budapest,
Hungary, 911 June 2005
Methods 1.
Questionnaire study Interviewers 2007
standardized questionnaires Nyergesújfalu,
Hungary (asbestos cement factory) gt35
years Both genders
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ISEE/CEEC Meeting, Budapest,
Hungary, 911 June 2005
Methods 2.
Data processing Data entry Epi Info 6.04d
Analysis Stata 7.0 Occupationally exposed to
asbestos excluded Crude odds ratios (cORs) /
adjusted ORs (aORs) (gender, age groups of
10 years, smoking behaviour) 95 confidence
intervals (95 CI) 1470 subjects
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ISEE/CEEC Meeting, Budapest,
Hungary, 911 June 2005
Features of gt35 year oldsNyergesújfalu, Hungary,
1998
630 (of 1465, 43.0) male and 835 (57.0)
female Median age 53 years (interquartile
range4463 years) 745 (of 1466, 50.8)
smoked (currently or formerly) 11 (of
1450, 0.8) lung cancer 92 (of 1354,
6.8) worked gt20 years
in a dusty workplace 132 (of 1437, 9.2)
persistent mould in the flat
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Lung cancer cases and prevalences by gender, age
and smokingNyergesújfalu, Hungary, 1998
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ISEE/CEEC Meeting, Budapest,
Hungary, 911 June 2005
Associations of gender, age and smoking with
lung cancerNyergesújfalu, Hungary, 1998
Gender (male) cOR3.51, 95 CI0.9413.48
aOR3.28, 95 CI0.7913.70 Age (10 years)
cOR1.40, 95 CI0.812.41 aOR1.43,
95 CI0.812.52 Smoking (current or past)
cOR1.69, 95 CI0.495.79 aOR1.25,
95 CI0.334.77 Goodness-of-fit
p0,73
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Lung cancer cases and prevalences by workplace
dustiness and mould in the flatNyergesújfalu,
Hungary, 1998
0

7 3 7 4 N
- - Dusty
workplace, Persistent mould gt20 ys
in the flat (2-sided Fisher exact test
plt0.05)
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ISEE/CEEC Meeting, Budapest,
Hungary, 911 June 2005
Associations of dusty workplace and mould with
lung cancerNyergesújfalu, Hungary, 1998
Dusty workplace for gt 20 years
cOR6.10, 95 CI1.5523.99 aOR4.17,
95 CI1.0216.88 Goodness-of-fit
p0,92 Persistent mould in the flat
cOR5.76, 95 CI1.6619.96 aOR6.13,
95 CI1.7321.67 Goodness-of-fit
p0,81 plt0.05 plt0.01
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ISEE/CEEC Meeting, Budapest,
Hungary, 911 June 2005
Conclusions
A strong assocation (even if adjusted) mould
in the flat lung cancer E. g. aflatoxin B1
IARC Class 1 human carcinogen It is to
consider the possible carcinogenic role of
airborne mycotoxins The number of lung cancer
cases few The association highly
significant Further literature and field
research is needed
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ISEE/CEEC Meeting, Budapest,
Hungary, 911 June 2005
Thank you for your attention!
E-mail varromj_at_okk.antsz.hu
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ISEE/CEEC Meeting, Budapest,
Hungary, 911 June 2005
A model for lung cancer Nyergesújfalu, Hungary,
1998
Gender (male) mOR3.18, 95 CI0.6914.72 Ag
e (10 years) mOR1.49, 95 CI0.792.81 Smok
ing mOR1.06, 95 CI0.254.46 Dusty
w. gt 20 ys mOR3.67, 95 CI0.8915.08 Mould
in the flat mOR6.67, 95 CI1.7725.18
Goodness-of-fit
p0,94 plt0.01 (Statistical validation not
possible!!!)