LIPOSOMES

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LIPOSOMES
The lamellar phases of phospholipids wherein
stacked phospholipid bilayers are separated by
layers of the aqueous phase convert spontaneously
into multilamellar liposomes at increased water
content.
Unilamellar phospholipid liposomes are hollow
spherical particles consisting of single
phospholipid bilayer shell with the aqueous phase
inside and outside of this shell.
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Neutron scattering and LLB http//www-llb.cea.fr/
index_e.html
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SANS
Polydispersity
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Evaluation
Guinier approximation
Fit
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Models
Single-shell
Multi-shell
Multi-shell Linear profile of headgroup
Multi-shell Triangular profile of headgroup
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Contrast Variation and Guinier approximation
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Contrast Variation and Fitting
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Effect of additional amphiphilic molecules
Thin disc with thickness h r1
Full sphere with radius R r3
Hollow sphere with radii R1, R1 r1 (thin layer)
Full cylinder with radius R r2
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YUMO
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PAXE
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