Title: Fulcrum SP Technology
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2Fulcrum SP Technology
- SPs A New Class of Highly Stable Proteins -
- One Molecule with Multiple Applications
- SP1 is isolated from plants
- SP1 has a repair and protection capability at low
concentrations - SP1 activity does not require externally added
energy source - Low cost of large-scale production
- Forms a complex which can serve as a molecular
scaffold
3Fulcrum SP Products
- One Molecule with Multiple Applications
- Native SP1
- Recombinant SP1
- Tailor-Made Products
- SP Scaffold
5 nm
4Mission Statement
- Fulcrum will revolutionize the field of protein
stabilization and repair technologies for the
multi-billion dollar protein based industries.
5Market Needs
- Proteins have multiple applications but they are
inherently unstable. - The stabilization and repair of proteins will
benefit the multi-billion - dollar industries of protein based products.
Need
Stage
Improve production media Improve tissue culture
media Assist protein folding
Manufacturing
Extend product shelf life Reduce the need for
cold storage Alleviate the need for freeze drying
Storage
Increase activity stability during
operation Repair damaged proteins
Performance
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7DiagnosticsSP1 improves the performance of
commercial ELISA-baseddiagnostic kits (b site)
Control
Activity ()
40 µg/ml SP1
100
50
0
0
1
7
Time (weeks)
8One Molecule with Multiple Applications
Diagnostics
Protein Manufacturing
Skin Hair Care
9SP1 Repairs Industrial Enzymes Example a-amylase
no SP1
160
with SP1
120
Relative activity ()
80
40
0
Two hours at room temperature
Untreated
10One Molecule with Multiple Applications
Diagnostics
Industrial Enzymes
Skin Hair Care 83B
Anti-aging reagents Protects and repairs hair
protein Stabilizes skin care products
Protein Manufacturing
11Hair CareSP1 Strengthens human hair
Control (untreated)
120
SP1 treated
100
Weight (gr.)
80
60
40
20
0
1
2
3
4
5
6
7
8
9
Hair sample number
12Skin CareSOD activity is stimulated by SP1.
(Superoxide Dismutase is an enzyme that protects
the skin from free radicals.)
SOD Activity ()
SP1 Concentration (mg/ml)
13Self-Assembled Scaffold Multivalent display of
functional protein domains
Protein A
Diagnostics New technology for single step
diagnostic reagent Industrial Enzymes New
enzyme to facilitate step-wise reactions
Protein G
Scab
Growth Factor
Protein L
HRP
14Fulcrum SPs Solutions
- Native SP1, Recombinant SP1
- SP Scaffolds
- Tailor-made products for
- Diagnostics
- Industrial Enzymes
- Self-assembled nano-structures
- Active Component in
- Skin and hair care products
- Tissue culture media
- Additives to existing products for
- Protection against inactivation while in
production, storage and performance stages
15Long-Term Applications
- Agro-biotechnology (tolerance to salt and drought
stress) - Drug delivery
- Prevention of protein aggregation in the
treatment of - neuro-degenerative diseases
- Nanotechnology
16Market Position
- Market competition includes stabilizers (animal
derived proteins such as - albumin casein), polymers (polyethelyneglycol,
PEG), and sugars (glycerol). - The Fulcrum SP Competitive Edge
- Repair capabilities (works at low concentrations
its activity is ATP independent) - High durability low cost of production
- High stability
- Active under extreme conditions
- Safe and Natural - plant derived product
- SP Scaffold There is no competition for this
product
17FULCRUM SP - The Company
- Founded in January 2001
- Wholly owned by founders and private investors
- Patent pending for the entire SP group
- Exclusive license from the Hebrew University,
Jerusalem - Lab research facilities in Rehovot, Israel
18Business Strategy
- To become financially independent within three
years - Initial focus on applications with short
time-to-market, such as additives for diagnostic
kits, tissue culture media and industrial
enzymes. - Collaborate with major firms to develop and
commercialize SP-based products specifically
for skin and hair care markets - License the technology for other applications
especially for long term applications
19Executive Team
- Mr. Zvi Peer, MBA, CEO. Founder former
manager, Romtech - Electronics Ltd., responsible for bringing
Romtech to Tel Aviv Stock - Exchange
- Dr. Amnon Wolf, Business Development Manager.
Formerly affiliated - with Weizmann Institute and UC Berkeley, Project
Manager, Peptor Ltd. - Prof. Arie Altman, Scientific Director. Chair,
the Institute of Plant - Sciences and Genetics in Agriculture, The Hebrew
University of - Jerusalem.
- Prof. Oded Shoseyov, Scientific Director. Senior
lecturer, The - Hebrew University of Jerusalem, Scientific
founder of CBD- - Technologies Ltd.
20Investment History
- 2001 - Initial investment by founders, friends,
family and grants - 600 K - FulcrumSP is seeking an equity investment of
2.5 M in order to - Accelerate the RD program
- Scientific manpower facilities
- Production optimization (upscale)
- Intellectual property
- Safety tests
- Pursue various strategic partnerships in Europe
and USA - Implement beta test sites
21Milestones for Two-Year Plan
- Large-scale production of Native SP1 and rSP1
- Two significant supply contracts
- Development contract of Scaffold SP1 with a
- multinational company
- Sub-licensee agreement with major firm
22Short Term Budget in K
23Specific Applications Timeline
Legend Feasibility studies
b -site Product launch
and first sales
24Income Statement Forecast (in Millions)
Revenues
Net profit
40
30
20
In millions of
10
0
-10
6th Year
3rd Year
2nd Year
1st Year
25International Recognition
Fulcrum SP attended the Capital IT Conference in
Paris, Spring 2002, and was awarded
- Top prize for International Potential of the
Company - One of the top four for Innovation Potential of
the Product - One of the top four for The Best of the Best
40s
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