TaySachs

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Tay-Sachs
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Definition

• Tay-Sachs disease is a rare inherited disorder
  that causes progressive destruction of nerve
  cells in the brain and spinal cord (the central
  nervous system

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Causes and risk Factors

• risk Factors
• The genetic mutations that cause this disease
  are more common in people of Ashkenazi (eastern
  and central European) Jewish heritage than in
  those with other backgrounds

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• Causes
• Tay-Sachs disease is a fatal genetic lipid
  storage disorder in which harmful quantities of a
  fatty substance called ganglioside GM2 build up
  in tissues and nerve cells in the brain. The
  condition is caused by insufficient activity of
  an enzyme called beta-hexosaminidase A that
  catalyzes the biodegradation of acidic fatty
  materials known as gangliosides. Gangliosides are
  made and biodegraded rapidly in early life as the
  brain develops

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• Symptoms
• The symptoms first appear at about the age of
  six months when an apparently healthy, happy baby
  stops smiling, crawling or tuning over, loses the
  ability to grasp or reach out, and gradually
  becomes blind, paralyzed and unaware of the
  surrounding world.

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• Treatment
• There is no cure or treatment to date that
  will prevent the disease from running its fatal
  course. Affected children can only be made as
  comfortable as possible

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• Prevention
• Prenatal diagnosis
• selective abortion
• Mate selection

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Questions

• Tay-Sachs disease is Effecting to the central
  nervous system
• There is no cure or treatment to date that will
  prevent Tay-Sachs from running its fatal course
  true/false
• Tay-Sachs is transmitting through genetic
  mutations