Principles of Biochemistry 4e

1
Chapter 19 Nucleic Acids
2
Nucleotide
3
Nucleotide base sugar P Nucleoside base
sugar
4
Sugars
RNA DNA
5
(No Transcript)
6
RNA DNA
DNA RNA
7
Both DNA and RNA
8
Sources for the atoms of the purine ring.
9
Folic acid is needed by pregnant women for
nucleic acid synthesis and some amino acid
synthesis. Inhibitors that resemble folic acid
such as methotrexate are chemotherapeutic agents
.
10
Energy requirements. 8 ATPs to synthesize
AMP There is a salvage pathway that
permits reuse of bases.
11
(No Transcript)
12
(No Transcript)
13
(No Transcript)
14
(No Transcript)
15
(No Transcript)
16
(No Transcript)
17
Information
Nucleotides are linked to form
a polynucleotide chain.
Structure
18
DNA, the double helix
19
(No Transcript)
20
B-DNA
21
(No Transcript)
22

• Types of interactions in DNA
• Van der Waals
• Hydrophobic
• Hydrogen bonds
• Electrostatic repulsive needs Mg2

23
The decrease in absorbance is due to the
interaction of the stacked bases.