Fermentation pathways

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Fermentation pathways
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Three stages of metabolism
Note prokaryotes dont have mitochondria, electro
n transport and oxidative phosphorylation takes
place at the cell membrane
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Glycolysis
2 ATPs per glucose used 4 ATPs and 2
NADHs generated per glucose NET 2 ATPs, 2
NADHs Many of the 3C compounds can be used in
the synthesis of cell components.
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Pentose Phosphate Cycle
Glucose is also broken down by the PPC to
make NADPH and biosynthetic intermediates Takes
3 glucose (18C) and converts them to 2 fructose
(12C) 1 Glyceraldehyde-3-P (3C) 3 CO2
(3C) Generates 3 NADPHs in the process. These
are used for reducing reactions in
biosynth. Many of the intermediates 5C, 3C, 7C
are used in the biosynthesis of cell
material (see green dots on map)-------gt
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TCA Cycle
Pyruvate (3C) from gycolysis gets converted to
AcetylCoA (2C) and a NADH which is added to
Oxalacetic acid (4C) to give citrate (6C). The
acetylCoA gets oxidized to CO2, giving Oxalacetic
acid, 3 NADHs, 1 FADH2 and a GTP (converted to
ATP) This happens twice (each glucose gets
converted to 2 pyruvates in glycolysis). a-ketog
lutarate is a very important intermediate used in
biosynthesis
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Mitochondrial Electron Transport Chains
Very similar to standard bacterial aerobic
respiration chains
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Mitochondrial Electron Transport Chains
Very similar to standard bacterial aerobic
respiration chains
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Relationship of electron donors and acceptors
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Eo of electron donors and acceptors in the
mitochondrial electron transport chain
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Mitochondrial Electron Transport Chains
Very similar to standard bacterial aerobic
respiration chains
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ATP synthesis by electron transport chains
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Iron precipitation at near an iron mine Iron
rich (Fe2) anaerobic waters become oxygenated at
the surface
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Bog iron ore from Poland
Precipitated iron seeping from an iron bog in
Colorado
Bog iron ore from coastal Virginia swamps
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