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Cytochrome P450

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Phenobarbitone. CYP 2 D 6. Substrate. Cisapride. Terfenadine. Ca Blockers. Sex Hormones ... Phenobarbitone. CYP 3 A 4. Substrate. Theophylline. Caffeine. Elavil ... – PowerPoint PPT presentation

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Title: Cytochrome P450


1
Cytochrome P450
Competition
Substrate
Inducers ?
Inhibitors ?
2
Cytochrome P450
Competition
Substrate
Inducers ?
Inhibitors ?
3
Cytochrome P450
Competition
Substrate
Inducers ?
Inhibitors ?
4
CYP 2 D 6
Substrate B-Blockers Desipramine Fluoxetine Parox
etine Codeine Oxycodone
Inhibitor Fluoxetine Paroxetine Sertraline Quinid
ine
Inducer Rifampicin Phenobarbitone
5
CYP 3 A 4
Substrate Cisapride Terfenadine Ca Blockers Sex
Hormones Cyclosporin Lovastatin
Inhibitor Macrolides Antifungals Grapefruit Juice
Inducer Rifampicin Phenobarbitone
6
Substrate Theophylline Caffeine Elavil Impipramin
e Remeron Olanzapine
CYP 1 A 2
Inhibitor Fluvoxamine Ciprofloxacin
Inducer Omeprazole Smoking
7
www.drug-interactions.com
8
www.drug-interactions.com
9
www.drug-interactions.com
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