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Molecular Imaging to Guide Personalized Cancer Therapy:

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Molecular Imaging to Guide Personalized Cancer Therapy: Predicting Multidrug Resistance-Mediated ... TIME (min) Tc-SESTAMIBI CONTENT ( fmol / mg protein nM ) o ... – PowerPoint PPT presentation

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Title: Molecular Imaging to Guide Personalized Cancer Therapy:


1
Molecular Imaging to Guide Personalized Cancer
Therapy Predicting Multidrug Resistance-Mediated
Chemotherapeutic Failure by Dynamic
Scintigraphic Imaging of MDR1 P-glycoprotein
(Pgp) Transport Activity In Vivo
Multidrug Resistance P-glycoprotein A Membrane
Transporter of Chemotherapeutic Drugs
Selected Radiopharmaceuticals are Transported by
P-glycoprotein
Expression of Recombinant Human MDR1 in Host Sf9
Cells Effect on Tc-99m-Sestamibi Accumulation
David Piwnica-Worms, M.D., Ph.D. Washington
University Medical School Molecular Imaging Center
Pgp
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