Ketogenesis

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Ketogenesis

• Ketogenesis is a process by which acetyl
  CoA is converted into ketone bodies (acetoacetic
  acid, ?-hydroxybutyrate and acetone).
• Acetoacetic acid, and ?-hydroxybutyrate
  are distributed to peripheral tissues (muscle,
  brain) to be used for ATP production.
• HMGCoA (hydroxymethylglutaryl CoA) is a
  key intermediate in ketogenesis as well as sterol
  synthesis.

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Ketone Bodies
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Fate of Ketone Bodies
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During untreated diabetes, severe dieting, and
fasting ketogenesis and gluconeogenesis increase
- there is an over-production of ketone bodies
p617-618 Lehninger