Hibernation,%20Aging%20and%20Longevity

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Hibernation, Aging and Longevity

• Natalia S. Gavrilova
• Leonid A. Gavrilov
• Center on Aging, NORC/University of Chicago,
• 1155 East 60th Street, Chicago, IL 60637

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Study of Turkish hamsters, Science, 1981
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Hibernation and longevity

• a) Longevity of all hamsters in the study.
• b) Longevity of the poor, moderate and good
  hibernators in the study

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Hibernation correlates with longevity
r0.522 plt0.001
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Distribution of deaths in (a) control and (b)
experimental hamsters

• Number of deaths against age at death at
  intervals of 60 days for
• a) control hamsters (mean 812 days, median
  843 days)
• b) experimental hamsters (mean 914 days, median
  884 days)

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Hibernation and Longevity in Bats
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Hibernation and Longevity in Bat Species

• (a) Average longevity for bat species that do and
  do not hibernate.
• Numbers indicate sample size in each category.
• (b) Average change in longevity between
  phylogenically independent comparisons in which
  hibernation was acquired.

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Predictors of longevity in bats based on ANCOVA
for species and bivariate analysis of contrasts
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Hibernation is not continuous!

• There are cycles of hibernation and short
  awakening
• (every week in ground squirrels)

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You don't need to hibernate in order to delay
aging

• Hibernation signals (darkness) may be
  sufficient!

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Study of Siberian Hamster
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Day length and reproductive success in females of
Siberian hamsters

• A) Reproductive success of long-day (LD),
  short-day (SD) and short-day pinealectomized
  (SD-PX) females expressed as the percentage of
  females mated at 9 mo of age that delivered live
  litters.
• B) Mean SEM live litter size at birth and
  weaning.

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Short-day exposure and delaying reproductive
senescence in females of Siberian hamster

• Mean SEM number of primordial follicles per
  ovary in SD and LD females at 13 and 26 wk of
  age. Asterisk () denotes significant effect of
  photoperiodic treatment at both ages

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Growth curves for hamsters subjected to LD and SD
exposure

• Mean SEM body mass (grams) of LD, SD, and SD-PX
  females from weaning at Postnatal Day 18 to 40 wk
  of age.

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Conclusion

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Study of Black Bears
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Black bear active and hibernating
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Hibernating Bears are Hot!

• Body temperature 30 - 34 C Reference Carey
  HV, Andrews MT, Martin SL.  Mammalian
  hibernation cellular and molecular responses to
  depressed metabolism and low temperature. Physiol
  Rev. 2003 Oct83(4)1153-81. Review. PMID
  14506303

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Hibernating bears do not experience osteoporosis
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What About Humans?
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