BIOMEDICAL IMAGING PROGRAM

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NATIONAL CANCER INSTITUTE
BIOMEDICAL IMAGING PROGRAM
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New NCI Initiatives for CAD

• Laurence P. Clarke PhD.
• Barbara Y. Croft PhD.
• Edward Staab MD.
• Daniel Sullivan MD.

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NCI
Division of Cancer Treatment and Diagnosis (DCTD)
Cancer Diagnosis Program (CDP)
Develop- mental Therapeutics Program (DTP)
Cancer Therapy Evaluation Program (CTEP)
Radiation Research Program (RRP)
Biomedical Imaging Program(BIP)
Diagnostic Imaging Branch
Molecular Imaging Branch
Image-guided Therapy Branch
Imaging Technology Development Branch
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NIH Funding for Imaging
Millions
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BIP Grant Funding
M
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Branch Imaging Technology

• Promoting new areas for imaging technology
  development.
• Development of new funding initiatives for
  academia and industry, including SBIR/STTRs.
• Development of research resources and centers of
  excellence.
• Promoting Inter-agency programs.

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NIH Initiatives Image Data Bases

• NLM/NSF Visible Human Project (1989-) CT/MRI
  images of to allow evaluation of image
  registration and segmentation (normal
  subjects/cadavers).
• NIH/NSF Human Brain Project (1993-). Common
  tools to facilitate research on neuroinformatics
  (CT/PET/MRI).
• NCI Database (2000-2005) Focused on evaluation
  of diagnostic software for specific cancer
  applications and impact of image pre- processing(
  image registration).

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Rationale Image Database

• CAD methods Rapidly being developed for more
  efficient analysis of screening studies (breast,
  lung and colon).
• Clinical Model Spiral CT for lung cancer
  screening for high risk patients Opportunity
  access to clinical trials.
• Physical Model Excellent for evaluating 3D CAD,
  image registration and temporal analysis of
  serial CT images, multi-modality image
  registration, image reconstruction.

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Objectives Image Database Resource

• Develop consensus for generation of retrospective
  image databases, histology confirmation and
  spatial ground truth, metrics and statistical
  methods for software evaluation.
• Provide an objective means to compare CAD, image
  processing, change analysis, and image
  reconstruction software methods.
• Stimulate development and early identification of
  promising software methods and reduction of
  research risk for academia and industry research
  sites.
• Enhance inter-disciplinary research collaboration
  by academia, federal laboratories and industry.

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Subtle and Very Subtle Nodules Imaged on CT scan
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CU0138-1
Jun 17 1996, (X,Y) resolution 0.68359 mm, Slice
thickness 1 mm
A.P.Reeves, Cornell University, 1999
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CU0138-1 3D Views
Volume 193.531 (mm3) Extents (x, y, z) 11, 10,
7 (mm) Length, Width, Height (EOI) 9.63099,
7.67993, 4.99717 (mm) Aspect Ratios (L/H, L/W,
W/H) 1.92729, 1.25405, 1.53686
A.P.Reeves, Cornell University, 1999
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U01 Cooperative Agreement

• Support 5 academic sites with fundable scores,
  selected by NCI, with ongoing lung cancer
  screening programs, to form a Lung Image Data
  Base Consortium (LIDC).
• LIDC Minimum of 3 sites and two X-ray CT
  systems.
• U01 Assistance mechanism as opposed to a
  contract.
• Steering committee PI and Co-PIs and NCI
  Program staff responsible for forming consensus
  on research tasks.
• Concept Support 7M for 5 years for 5 sites.

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Future Plans Technology Development

• Proposed PA R21/R33 phased innovation for
  imaging technology development.
• RFP for ultrasound research interface
• RFA for spiral CT image database
• Proposed additional Centers with technology
  development component

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NCI BIP WebPage

• URL www.nci.nih.gov/dip/
• Email Newsletter js95x_at_nih.gov
• lclarke_at_mail.nih.gov
• croftb_at_dtpepn.nci.nih.gov