Implantable Photocrosslinked Elastomer Delivery System for InterferonGamma

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CHEE 340 Tutorial 4
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Biomaterials Ceramics

• _____________ are used to repair and replace
  diseased and damaged parts of the musculoskeletal
  system.
• The applications of bio - ceramics in
  orthopaedics include
• -
• -
• -
• A porous ceramic is formed by _____________ a
  second phase.
• Dense, uniform and fine grained ceramics are
  formed by a process called _______________________
  ___.

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Biomaterials Ceramics

• The mineral phase of bone is _____________________
  _____.
• _____________ in bone makes it visco - elastic.
• Ceramics are classified as _____________,
  _____________, _____________ and _____________
  based on their tissue response.
• The advantages of bio - ceramics include
• -
• -
• -
• _____________ is the major disadvantage of bio -
  ceramics.

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Biomaterials Polymers

• As n increases -(CH2)n- the polymer becomes a
  _____________.
• A few applications of polymer use include
  _____________, _____________, _____________ and
  _____________.
• Natural polymers are _____________ while
  synthetic polymers are _____________.
• Polymers exist as _____________ polymers or as
  _____________ polymers.
• A low Tg in a polymer implies ____________________
  ______.
• The factors that influence Tg are
  __________________________, ______________________
  ____ and __________________________.

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Biomaterials Polymers

• Tg is a phenomenon of the ________________________
  __ regions in a polymer.

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Biomaterials Polymers

• The three types of crosslinking seen in polymers
  are _____________, _____________ and
  _____________.
• _____________ increases the molecular weight of
  elastomers.
• The interactions between polymer implants and the
  biological environment across the polymer -
  tissue interface include
• -
• -
• -
• Flux is dependent on the _____________ and
  _____________ of a component in a polymer.

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Biomaterials Polymers

• The advantages of biodegradable polymers include
• -
• -
• The disadvantages of biodegradable polymers
  include
• -
• -
• The degradation of polymers in a biological
  system happen through __________________________,
  __________________________ and____________________
  ______.

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Biomaterials Polymers

• Hydrolytic degradation begins with the absorption
  of _____________ from the tissue.
• The rate of hydrolytic degradation on
• -
• -
• Esters and anhydrides produce _____________
  during degradation which leads to a process
  called __________________________.
• Homogeneous hydrolytic degradation is called
  _____________ erosion while heterogeneous
  degradation is called _____________.
• Mass loss is considerable in _____________
  erosion.
• A considerable decrease in molecular weight in
  seen in _____________ erosion.

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Biomaterials Polymers

• Oxidative biodegradation occurs by
• -
• -
• Natural polymers degrade by ______________________
  ____.
• The most common enzymes that cause degradation of
  natural polymers include
• -
• -
• -

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