PowerPoint bemutat

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University of Debrecen, Hungary Knowledge
transfer at crossroads regional knowledge
diffusion through collaborative applied research
activity the regional knowledge centre
concept GENOMNANOTECH GND - DEBRECEN Enterpris
e Incubation Programme (EIP) Co-ordinators Prof
. László Fésüs Health Science Centre, H-4012
Debrecen, Nagyerdei krt. 98. Tel [phone],
e-mail fesus_at_indi.biochem.dote.hu dr. Miklós
Györffi Health Science Centre, H-4012 Debrecen,
Nagyerdei krt. 98. Tel [phone], e-mail
gyorffi_at_jaguar.unideb.hu
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New Life Science Building
Chemistry Building
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EIP Housing
University Main Campus
EIP
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Medical and Health Science Centre
X
EIP housing
EIP
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• Debreceni University Research University
• More than half of academic staff has scientific
  degree (out of this 52 in Life Sciences)
• roughly 150 PhD degrees awarded each year (almost
  half in Life Sciences) 23 scientific fields
• One third of the budget is R D income and
  expenditure (more than 90 of the income from
  international R D grants and contract research
  is in Life Sciences)

EIP
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Available Space

• The new Life Science Building
  17.000m2
• From this research laboratories (183)
  4.270m2
• Free space available
  5.800m2
• For enterprise incubation
  2.000m2
• For the establishment of significant plants
• University Industrial Park 25ha
• Industrial parks of City of Debrecen and of the
  region
• Spin-off activity
• 2005 national call EU structural grants 8
  application (all Life Sciences)

EIP
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Leading Edge Technologies in the Debrecen
University Region Applications in Genomics,
Nano- and Biotechnologies GENOMNANOTECH
DEBRECEN(GND)

• National Office for Research and Technology
  grant
• establishment of Regional Knowledge Centres
• goal to concentrate material resources on those
  places and speciality fields, where there is a
  high level of research and there is industrial
  background capable to valorify RD results
• amount 7 million grant for 17 partners
• 1 million contribution of industrial
  partners

EIP
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GENOMNANOTECH DEBRECEN Regional Knowledge
Centre

• Partners
• non profit (supporting the consortium)
• Council of Debrecen City,
• Council of Hajdú-Bihar County,
• North-Great Plain Region Development Agency,
• Chamber of Commerce and Industry of Hajdú-Bihar
  County,
• Euroregion House Co. for Public Benefit,
• International Trade Development Hungary

• for profit
• Consortium partner 16
• Other partners 11
• Partners in other significant and linked projects
  100

• from this
• in Debrecen 6
• in Hajdú-Bihar county 1
• within 60 - 70km 3
• further 7

EIP
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Programs and tasks
GENOMENANOTECH
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Core facilities

• Genomics Center
• Real-time quantitative PCR
• Microarray experiments
• full range of genomics technologies including
  automatic DNA sequencing, gene expression array
  technologies, profiling, genotyping
• Bioinformatics
• Other facilities provided for EIP purposes
• HPLC and full analitical range of Mass
  Spectrometers
• Cell culture facilities
• Flow cytometry
• Confocal and deconvolution microscopy
• Imaging (PET, MRI, SPECT)
• scanning and transmission EM, atomic force
  microscopy

GENOMENANOTECH
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Implementation, timing, results
GENOMENANOTECH
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Business support services

• Staff development
• Economist (business plan, etc.)
• Legal advisor (general IPR, company law, product
  regulations, etc.)
• Network
• specialised IPR service provider(s) patent
  application process management, PCT management,
  patent and novelty search, issuing contracts for
  licensing and invention fees, representation
  against national and international patent
  authorities
• legal services
• national (Hungarian Bank for Development) and
  international partners (European and investment
  Genopole-BioLink, SGAM, EIB, EIF)

GENOMENANOTECH
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GENOMENANOTECH
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Examples of current incubation projects

• Cell Therapy Clinical Centre Omninvest Ltd.
  (2003)
• Operating Areas and Primary Goals of the Center
• introduction of dendritic cell-based vaccination
  in the therapy of malignant diseases
• introduction of autologous stem cell therapies in
  several areas of medicine
• manufacturing of gene-therapeutical products
• international cooperation
• Achievements by April 2005
• Autologous Bone-marrow Transplantation Unit
• phase I-II clinical trial for the
  immuno-therapeutical treatment of colorectal
  cancer (Dukes B2, C) (12 patients autologous
  dendritic cell therapy)
• Investment Omninvest 2.5 million
• DUMHSC 1.5 million

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Examples of current incubation projects

• Ad-Ex-Go Research Inc. (2004)
• Experimetria Ltd. biomedical research and
  manufacture
• http//www.experimetria.hu/main.html
• PRS Ltd. performance of clinical trials
• Acusticus Ltd. hearing aid devices
• Goodwill Research Ltd.
• Contract Research Organization to organize
  human Phase I-IV trials for the pharmaceutical
  industry.
• http//www.gvm.hu/
• Adware Research Ltd. quality management service
• Zelion Pharma Ltd. drug production and delivery
  service
• Debrecen University

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Examples of current incubation projects

• Ad-Ex-Go Research Inc. (2004)
• Preclinical Services
• Safety pharmacology studies - assess the
  potential adverse effects of a compound on the
  physiologic function of one or more organs, or
  organ-systems, in either intact or acutely
  prepared models that are of proven relevance to
  human, whether healthy or sick
• pharmacology - evaluation of any effect of a
  compound on any biological target
• Clinical Services
• Phase I studies - safety/ maximally tolerable
  dose/pharmacokinetic parameters
• Bioequivalence studies
• Phase II-IV studies - for regulatory and ethical
  permissions, clinical trial related drug
  transport, protocol development and/or writing,
  patient information and informed consent
  development and/or writing, CRF design
  typographical implementation, investigator
  selection, study related training and GCP
  courses, Project Management, monitoring and
  related administrative services from feasibility
  studies to study closure visits including SAE
  reporting to the sponsor and authorities, CRA Out
  Sourcing Service

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Examples of current incubation projects

• Ad-Ex-Go Research Inc. (2004)
• Services to preclinical and clinical studies
• quality assurance GLP or GCP audits
• data management, statistical planning and
  biostatistical evaluation
• technical development and manufacturing workshop
• Regulatory affairs
• Other related services
• quality management related activity
• control, calibrate and/or verify for monitoring
  and measuring devices
• Education

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Examples of current incubation projects

• Biosystems International (2004)
• Primary focus disease and/or mechanism specific
  protein biomarkers - surrogate markers which can
  indicate disease progression and efficacy of new
  or marketed compounds before visible changes in
  clinical parameters become apparent
• Quasi co-incubated with Genopole/ Evry, France
• Debrecen patient, biobank and molecular
  resources
• Chronic and life threatening diseases patient
  collections
• High quality clinical teams, with international
  experience
• Electronic patient database (custom prepared)
• Biobank Plasma, urine, DNA, tissue
• Genomics team genetic testing, molecular
  profiling
• Biosystems Intl. at the University of Debrecen
  hybridoma and genetic testing laboratories

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Examples of current incubation projects

• Biosystems International (2004)
• Genopole support
• Expert consultants for BP concept and writing,
  business definition
• Help to locate and present to venture capitalists
  and other resource potentials
• Identification of potential solutions for
  business management issues accounting, banking,
  IP, contract management
• Continued monitoring of needs and provision of
  suitable work environment
• Office space, laboratory space
• Grant for shared laboratory instruments cell
  freezing station
• Provision of logistics and secretarial help to
  establish professional status and image
  telephone service, mail service, shipments
  receiving, security service
• Fostering of internal collaborations by the
  identification of shared needs and potential
  complementarities (BD aspects)
• Biosystems Intl. at Genopole Evry HQ,
  management, hybridoma and screening, mass
  spectrometry and systems biology laboratories

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Some of major recent projects in LifeSciences at
DU MHSC

• EU-FP5 Research Centre for Molecular Medicine
  Improvement of Quality of Life Through Research
  and Education/Centre of Excellence project
• EU FP6 Hungarian Network of Excellent Centers an
  Nanoscience
• EU FP6 HUMGERI - Human Genomic Research
  Integration genetic research to approach
  systematic study of morbidity and mortality
  factors in Hungary
• NKFP-1A/008/04 Molecular analysis and therapy of
  deseases affecting large human populations with
  the tools of functional genomics (7 enterprises)
• NKFP-1/007/01 Functional and Chemical Genomics in
  the Prevention, Diagnosis and Treatment of
  Specific Diseases (6 enterprises)
• PFIZER Genetic screening of specific human
  diseases
• CRC/2004 Programme for the establishement of
  Debrecen Pharmainnovation Co-operative Research
  Centre (CRC) for the research, development of
  original and modified human phamraceuticals and
  training of specialists in pharmaceutical
  industry (6 enterprises)

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Research Centre for Molecular Medicine (RCMM)

• EU FP5 (1998-2002)
• Joint call for proposals for indirect RTD actions
  under the specific programmes for research,
  technological development and demonstration on
  for Newly Associated States
• Quality of life and management of living
  resources
• Competitive and sustainable growth
• Energy, environment and sustainable development
• Aim support a number of outstanding research
  centres to better put their capabilities at the
  service of the economic and social needs of these
  countries

RCMM
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Research Centre for Molecular Medicine

• Organigram

SUPERVISORY BOARD
INTERNATIONAL ADVISORY BOARD

• MANAGEMENT
• Research
• Education
• Finance
• Innovation
• Bioethics

RESEARCH GROUPS
RCMM
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Research Centre for Molecular Medicine

• Workpackages
• Advancing Human Genomic Research
• Restructuring the Clinical Research Unit
• Networks in Molecular Medicine
• Molecular Imaging and Nanobiotechnology
• Channelopathies
• Apoptosis
• Thrombosis and Haemostasis
• Strengthening the role of the Centre in EMBO
• Eurodoctorate in Biotechnology
• European workshop of doctoral students
• International Advisory Board

RCMM
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WP1 Advancing Human Genomic Research through
Integration, Networking and Exchange Programmes
Co-ordinator László Nagy
Aims are to 1) establish a Regional Genome
Facility and provide access for academic
institutions and under regulated conditions
for the industry. 2) set up an internet home
page for the RCMM Genomics Research Unit,
explaining in detail the experimental and
bioinformatics capabilities, as well as providing
summaries of the research projects supported by
the Genomics Research Unit. 3) initiate
collaborative projects with Hungarian and
international partners, for optimal utilization
of expertise and resources. 4. organize basic
and advanced level training courses and workshops
with international participation, and yearly
Genomics Symposium. An integral part of the
genomics programme is the Bioinformatics Support
Framework for in silico investigations, data
warehousing and data mining. 5. initiate a
student and postdoctoral exchange programme with
2-month fellowships with other EU genomics
research institutes (DKFZ, University of
Manchester, EMBL)
RCMM
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WP2 Restructuring the Clinical Research Unit
(CRU)
Co-ordinator László Muszbek
RCMM has decided to put more emphasis on
promoting research concerning the pathomechanism,
epidemiology, prevention and control of diseases,
utilizing the unique opportunities provided by
the University Hospital

• STEPS
• Establishing an expert panel to work out details
  concerning the restructuring, development and
  functioning of CRU.
• Consolidating presently available research
  facilities and developing new research units or
  research supporting units within CRU.
• Series of discussions with chairpersons of
  clinical departments will be carried out and the
  development of specific clinical research teams
  within CRU will be decided.
• Recruiting PhD students from Hungary, the
  neighbouring countries and EU member states,
  special emphasis will be put on recruiting PhD
  students among physicians from clinical
  departments.
• Inviting leading clinical researchers from EU
  member states to give lectures/courses.
• Sending PhD students and senior scientists to
  leading EU centres of clinical research.
• Educating the public through local and national
  media as well as the website of the CRU about the
  importance of clinical research in general and
  about the importance of research carried out at
  CRU, in particular.

RCMM
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WP3-6 Networks in Molecular Medicine
WP3 Nanobiotechnology Co-ordinator Sándor
Damjanovich WP4 Channelopathies Co-ordinator
László Kovács WP5 Apoptosis Co-ordinator
László Fésüs WP6 Hemostasis Co-ordinator
László Muszbek
Aims are to WP3. build a European Network based
on existing collaborations to develop
cutting-edge molecular imaging and
nanobiotechnology methods that can serve as a
basis for future diagnostic and therapeutic
methods and to train experts in the
interdisciplinary field of nanobiotechnology.
WP4. strenghten existing collaborations in order
to make major advances in our knowledge and
understanding of ion channels in health and
disease. WP5. start a systematic training and
research programme on various aspects of cell
death for Ph.D. students and postdoctoral fellows
WP6. develop new research project by utilizing
the cooperative network of ETRO (European
Thrombosis and Hemostasis Organisation)
Approach Student and scientist exchange
programmes Training courses and conferences
RCMM
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WP7 Strengthening the role of the Centre in EMBO
Co-ordinator Sándor Damjanovich
Background EMBO (European Molecular Biology
Organisation) is a major propellant of scientific
progress in Europe both as a forum for exchanging
information and as a body financing and
evaluating research most relevant to molecular
medicine. The Director of RCMM is a member of
EMBO and Ambassador of Hungary to the EMBO
General Assembly. Our Institution hosted two EMBO
courses in the past.

• Aims of WP7 is to tighten the bonds with EMBO by
• visits of junior and senior scientists form RCMM
  to EMBO laboratories, core facilities (exploiting
  the EMBO Visitors Programme and
  courses/workshops at the EMBL) and labs of EMBO
  members
• visits and short courses, workshops by renown
  scientists at EMBO (members and EMBL researchers)
  to Debrecen
• major EMBO courses on topics of widespread
  interest, with participation of international
  experts in the field of molecular biology and
  molecular medicine.

RCMM
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WP8 Eurodoctorate in Biotechnology
Co-ordinator Pál Gergely
Background I. RCMM is the only Hungarian member
institution of HEDUBT (European Association for
Higher Education in Biotechnology), a European
organization aiming at providing mechanisms for
the transeuropean recognition of Higher Education
in Biotechnology at the Master and Doctorate
level. II. In 2001 our Institution has
Completed a EU-sponsored TEMPUS project titled
Restructuring and Integration of PhD Programmes
in the Field of Biotechnology According to EU
Practice in 2001.

• Objectives of WP8 are to
• strengthen the role of the Centre in HEDUBT
• increase number of PhD students receiving
  Eurodoctorate in Biotechnology
• add new elements to the European dimension
  of the Centres PhD
• education
• disseminate knowledge accumulated in the
  Centres PhD programmes more effectively

RCMM
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WP9 European workshop of doctoral students in
molecular medicine
Co-ordinator László Virág
Background It has been a long-lasting tradition
at the Centre that each year doctoral students as
well as undergraduate students participating in
research projects get the opportunity to present
their data and progress of their research work
The goal is to organize regular international
workshops at the annual RCMM PhD student
conference. Within the framework of the current
application one such workshop will be organized.
In case of success, these workshops will be
organized in triannual intervals.
RCMM
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WP10 International Advisory Board
Co-ordinator Sándor Damjanovich and László Fésüs
Aim is to establish a AB consisting of high
ranked scientists advising and assisting the
Centres management. The advice among other
things comprises the assessment of scientific,
financial, and educational activities and general
advice regarding strategic development issues.
Members of the Board Franco Celada Secretary
General of HEDUBT, University of Genova,
Italy Peter J. Davies Head of the Dept.
Pharmacology, University of Texas-Houston Maria
Benedatta Donati Universita Cattolica,
Campobasso, Italy Manfred Eigen Nobel Laurate,
Honorary Chairman, MPI Biophysical Chemistry
Göttingen Frank Gannon EMBO Executive Director,
EMBL, Heidelberg, Germany Heikki Helminen Head
of the Department of Anatomy, University of
Kuopio, Finland Thomas M. Jovin Head of the Dept
of Mol. Biol., MPI Biophysical Chemistry
Göttingen, Germany Norbert Kroó General Secretary
of the Hungarian Academy of Sciences Frank
Lehman-Horn Head of Dept. Applied Physiology,
University of Ulm Isreal Pecht Head of the
Department of Immunology, Weizman Institute of
Science, Israel George K. Radda Chief Executive
Officer of MRC, University of Oxford, United
Kingdom Peter Stanfield Professor of Molecular
Physiology, University of Warwick László Takács
Pfizer Global Research, Fresnes-Paris,
France Thomas A. Waldmann Chief of Metabolism
Branch, National Cancer Institute, Bethesda,
MD Giovanni de Gaetano Head of the Department,
Universita Cattolica, Campobasso, Italy
RCMM
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HUMAN GENOMIC RESEARCH INTEGRATION

• EU FP6 (2002-2006)
• Consortium of
• leading Hungarian research centres in Life
  Sciences
• Izinta Ltd.
• Hungarian Bioinformatics Research Ltd.
• Objective to structure and focus Hungarian
  genomic research in order to provide a new
  framework to approach morbidity and mortality
  statistics of the Hungarian population through
  the study of genetic as well as epigenetic
  factors
• Targets
• Structural and operational organization of an
  integrated human genomic program in Hungary based
  on studies and comparison of European human
  genome projects
• Formation of a stable bioinformatics background
  for genomic activities
• Development of a biobanking system
• Establishment of a network of Hungarian SME's
  related to human genomics projects
• Clarification of ethical and legal aspects of
  genomic research
• Organization of a COGENE Conference t(EU) to
  provide a forum for genomic initiatives

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Hungarian Network of Excellent Centers on
Nanoscience(HUNN FP-6510358 15.12.2003)

• Aims to contribute substantially to the
  Integration and Strengthening of the European
  Research Area in the field of Nano-technologies,
  nano-sciences, knowledge-based multifunctional
  materials and new production processes and
  devices (NMP), by means of specific support
  actions in Hungary
• Workpackages
• Creation of HUNN-NC
• Development of research and innovation strategies
• Technology transfer
• Promotion of Hungarian participation in EC
  programmes
• Dissemination, IPR, communication
• Education and training
• Management
• 12 partners, UD nanobiotechnology

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Prof. J. Craig Venter (2003)
Debrecen Award for Molecular Medicine
Sir Philip Cohen (2004)
The Medical and Health Science Center of the
University of Debrecen has founded an
international annual prize in molecular medicine.
The award recognizes significant advances in the
fields of molecular medicine with demonstrated
benefits applied to improved patient care.
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Thank you for your attention !