Project hFABP

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Project h-FABP

• Evaluation of Early Marker for the Detection of
  AMI
• 04 June 2004

Scientific Secretary SEMESIsquemic Myopathology
Group
Dr. Luis García-Castrillo
Project financed by
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Reliability of current marker for AMI
995 patiens with suspected AMI
R. Fromm Cardiovascular 20022341-5
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Objective of the Study

• Evaluate the suitability to use the level in
  blood of heart-specific Fatty Acid-Binding
  Protein (h-FABP) as early marker for acute damage
  of the myocardium.

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Study Design

• Evaluation of the diagnostic reliability of
  cardiac markers. Prospective, consecutive, and
  multicentric.
• Evaluation of CardioDetect, with a threshold
  for h-FABP of 7ng/ml.
• Diagnosis Clinical diagnosis and enzymatic
  measurement.
• Series Patients with chest pain symptomatic for
  AMI to which an evaluation procedure of certain
  markers is applied during a certain observation
  time.

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Inclusion Criterion

• Chest pain with suspected AMI
• Symptom start between 20 minutes and 4 hours.
• Possibility to get a final diagnosis after the
  testing.

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Intervention

• Extraction of full blood and application on the
  rapid test for h-FABP CardioDetect.
• Determination of Troponin with the same
  extraction.

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Participating Centres
20 centres
H.C Santiago H. Do Meixoeiro
H.M. Valdecilla
H. Txagorrichu H. Basurto
H.Virgen del Camino
H. Miguel Servet
H.C.Salamanca H. Ntra.Sra. De Sonsoles
H.Clinic H. Sta. Creu i St. Pau H. Mutua Tarrasa
H.Princesa H.Puerta de Hierro H. Fund. Jimenez
Diaz
H. Verge de Toro
H.C.U Valencia
H.Ntra.Sra. Alarcos
H. Reina Sofia
H.Ntra.Sra.Candelaria
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Patients Characteristics
Age distribution
383 patients in total
Mean age 64.8 years (ds -14.6)
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Draw time after symptom onset
Accumulating percentage
Time with symptoms
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Time of first sampe draw after symptom onset
21
43
34
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Result of the first ECG
53 cases
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Distribution of Final Diagnosis
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Positive Markers following final diagnosis
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Results for Troponin
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Results for h-FABP
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Observed diagnostic reliability of h-FABP and
Troponin
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Comparation of the diagnostic reliability in
relation to draw time
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Diagnostic reliabilty of h-FABP and Troponin for
AMI without elevated ST
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Comparison of both markers
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Conclusion

• Use of h-FABP has shown to be helpful from the
  first hour on for triaging AMI.
• Its diagnostic reliability was significantly
  higher than that of Troponin, having classified
  correctly 79 of the patients.
• Its diagnostic errors related to False Negative
  results, which require a verification of the time
  of draw or of the interpretation of the test
  result.