1
??? 3

????? ????
???? 1
??? 3
2
?????

• ???? ?????? ???
• ?????? ????? ????
• ????? ?????
• ????? ??-?????
• ???? ????? ?? ?????? ????? ?????
• ??????
• ???? ??????

???? 2
??? 3
3
?????? ???

The fluid mosaic model
Cytoplasmic membrane, 10 nm
???? 3
??? 3
4
?????? ???

???? 4
??? 3
5
?????? ????? ????Cell Disruption
????? ??-??????
????? ??????
?????????
??????
?????? ????? ?????
?????????
????? ???????
????? ?????? ???????? ?????? ?????????
??? ??? ????????? ????? ????
???? 5
??? 3
6
?????????
???? ??? ???????- ?? ????
? ??????? ????? ? ????? K ? ????? ????? ? ?????
???? ??? ? ????? ??????
???? 6
??? 3
7
?????
???? ?????
? ????? ???-???? ???????????
? ????? ???? ???, ??? ??????
? ?????? ??????? ???-?????, ???????
???-?????-?????
? ?????? ??????? ???-?????, ???????
??? ????? ???????
???? 7
??? 3
8
????? ?????

????? ????? ?/?? ??? ??????? ?? ???? ??? ??? ????
??????? ???? ???? ????????? ??????? ??????? ?????
???? 8
??? 3
9
??????Homogenization

????? ?????? ???? ???? ??? ???? ???? ???? - ??
400 MPa
???? 9
??? 3
10
????? ???????

????? ?????? Homogenization valve
???? 10
??? 3
11
?????? ????
?????? W - ????? ????? c0 - ????? ????? ??????
?????? cf - ????? ?????? ?????? k - ??? ?????
??????? ???? ?????
W, c0
W, cf
????? ??????
???? ???
???? 11
??? 3
12
?????? ???? ?? ?????
?????? V - ??? ????? ????? W - ????? ????? t -
??? ????? c - ????? ????? ????? c0 - ????? ?????
?????? ?????? cf - ????? ???? ?????? ???? t k -
??? ????? ??????
W, cf
W, c
????? ??????
???? ???
V, c
???? 12
??? 3
13
?????? ???? ?? ????? (????)
(????? ?????)
(3.3)
(3.4)
???? 13
??? 3
14
?????? ????
R, cf
F, c0
?????? V - ??? ????? ????? W - ????? ?????
?????? F - ????? ???? / ???? R - ????? ????? c -
????? ????? ????? c0 - ????? ????? ????? cf -
????? ???? ???? ?????? k - ??? ????? ??????
W, C
?
F, cf
????? ??????
???? ???
V, C
???? 14
??? 3
15
?????? ???? (????)
(????? ?????)
???? 15
??? 3
16
???? ??????Bead Mill

????? ???? ??? ????? ???????? ???????????
???? 16
??? 3
17
??? ????? ????? ??????
??? ?????? ??????? ???? ?????
(3.7)
???? 17
??? 3
18
????? ????? ??????

???? 18
??? 3
19
?????

• ???? ????? ??????? ????? ?????? ?????
• ??????? ??-?????? ?????? ????
• ????? ????????
• ????? ?????
• ????? ????????
• ??? ????? ?????
• ?????? ???? ?????
• ???? ?????? ?????? ?????

???? 19
??? 3