arNOX, AGINGRELATED CELL SURFACE ECTONOX PROTEIN

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arNOX, AGING-RELATED CELL SURFACE ECTO-NOX PROTEIN

• D. James Morré and Dorothy Morré
• Department of Medicinal Chemistry Molecular
  Pharmacology and Department of Foods and
  Nutrition Purdue University, W. Lafayette,
  Indiana 47907

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Preventative target to reduceatherogenic risk in
the elderly
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SOD inhibited reduction of ferricytochrome c

• Human (Age gt 50y)
• Buffy coats
• Sera
• Saliva
• Perspiration
• Late-passage cell culture
• MCF-10A
• WI-38
• Plants
• Senescent spinach leaves
• Senescent Aracean spathes

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Morré, D.M, F. Guo and Morré, D.J. 2003 Mol.
Cell. Biochem. 254101-109.
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• Coenzyme Q (Q8, Q9 and Q10 but not by Q0, Q2, Q4,
  or Q7)
• Several Chinese botanicals with antiaging
  activities

Ar NOX inhibited by
Buffy Coats
Morré, D.M and Morré, D.J. 2003 BioFactors
1833-43
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Summary

• Aging-related NOX
• Generates superoxide
• Cells and sera of aged individual (gt50y)
• Postulated to propagate aging cascade to adjacent
  cells and circulating lipoproteins
• Ablated by coenzyme Q10 /Antiaging botanicals