Molecular Genetics Bio350516

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Molecular Genetics Bio350/516 Lecture 3, 1/24/06
Today I. Chapter 3 (continued) A. Protein
structure 1. Domains, motifs and
folding B. Discovery of the connection
between genes and proteins 1. Archibald
Garrod (alcaptonuria) 2. Beadle and
Tatum (Neurospora mutants) C. rRNA vs mRNA
as the molecule for protein information storage
1. Jacob, Brenner, Meselson experiment
D. Transcription E. Translation
1. tRNA nomenclature 2. Shine and
Dalgarno sequence 3. Peptidyl
transferase (a ribozyme!) 4. GTP, not
ATP, NRG source
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Protein Structure
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Figure 3.4
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Figure 3.5
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Figure 3.6
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Figure 3.8a
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Figure 3.8b
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Archibald Garrod and Alcaptonuria
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Figure 3.9
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Beadle and Tatum
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Edward L.Tatum
George W. Beadle
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Figure 3.10
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mRNA as Protein Information Storage
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Figure 3.12
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Figure 3.13a
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Figure 3.13b
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Transcription
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Figure 3.14
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Translation
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Figure 3.16
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Figure 3.17
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Figure 3.18
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Figure 3.19
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Central Dogma
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Figure 3.20