Chapter 18: Translation Elongation

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Chapter 18 Translation Elongation

• Today
• Review session Friday 5 pm and Monday 5 pm
• Chapter 18 Translation
• Prokaryotic elongation
• Eukaryotic elongation

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Direction of Polypeptide Synthesis and mRNA
translation

• Amino to carboxyl direction
• MRNA read 5' to 3'

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The Genetic Code

• Three base codons
• Non-overlapping
• No gaps
• Triplet code
• Highly degenerate 20 aa's, 64 codons, three stops

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Iso-accepting tRNA's and Wobble Pairs
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Universal Code

• frozen accident
• Exceptions
• Usually a stop codon that has been recruited to
  code for an amino acid
• Switched meaning usually in mitochondria
• Random code?

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