In Vivo DC Tracking

1
In Vivo DC Tracking
Non-mature DCs
Mature DCs
1 hour 4 Hour Day 1
1 hour 4 Hour Day 1
Rapid lung transit of Non-mature DCs compared to
Mature DCs
In Vivo Cell Biodistribution Quantitation
Node
4 Hour
Day 1
Day 2
Day 3
Above Mature DCs following SC injection into Rt
deltoid, axillary node demonstrated by Day1
Below Non-mature DCs following SC injection
into Lt deltoid, distal tracking demonstrated
4 Hour
Day 1
Day 2
Day 3

• Subcutaneous injection of mDCs demonstrated
  progressively increasing nodal accumulation up to
  72 hours after administration
• Minimum number of cells definitely demonstrable
  within a node is 27 x 103 with SC injection
• 150 x 103 cells accumulated at 72 hours, 1.3
  of initial dose

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