LifePak

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LifePak

• Technical Training for Medical Representative
  Certification
• Written by
• Carsten R. Smidt, Ph.D., F.A.C.N.

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The LifePak Family
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The LifePak Family
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Study Materials

• Copy of these slides
• Draft, LifePak Monograph
• For internal use only.
• Do not copy!

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Nutrition 101

• Present Knowledge in Nutrition
• Seventh Edition
• E. E. Ziegler and L. J. Filer, Jr.
• 1996, 684 pages, 50.00
• ILSI Press, 202-659-0074 x123
• ilsipress_at_ilsi.org

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Dont fall asleep!

• Possible Exam Items

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What you will learn

• Why take multivitamins?
• Concept of optimum supplementation
• LifePaks 5-in-1 concept
• antioxidants, free radicals heart health
• B-vitamins homocysteine
• bone nutrients osteoporosis
• trace elements bioavailability
• phytonutrients

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What you will learn

• LifePak Cardiovascular Health, Glucose
  Insulin Metabolism, and Immune Function
• Key features of other LifePak products
• LifePak Directions
• LifePak Safety
• LifePak Precautions

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In other words...

• LifePak is the best multivitamin/mineral
  supplement -- worldwide!

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Why take multivitamins?

• To meet the RDAs, I.e., prevent nutrient
  deficiencies
• To improve general well-being, e.g., physical and
  mental performance
• To stay healthy (health insurance in pill form)

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Multivitamin Usage

• 38 of US population are regular multivitamin
  users!
• What shall we do with the other 62 ?

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Recommended Dietary Allowances

• RDA Definition Intake level of essential
  nutrients judged to be adequate to meet the needs
  of practically all healthy persons.
• RDAs prevent classical deficiency diseases
• Vitamin C Scurvy
• Thiamin Beri-Beri
• RDAs have a safety margin Less than 2/3rds of
  RDA nutrient deficiency

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RDA, RDI, DVconfusing?

• RDA Recommended Dietary Allowances, NRC Food and
  Nutrition Board 1989.
• NRC Food and Nutrition Board 1998-?
• RDI Recommended Daily Intake, FDA, for
  labeling, based on 1978 RDAs.
• DV Daily Value, FDA, of RDI present in a
  serving of a food or supplement.

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Why take multivitamins?

• In a survey of 21,500 people, not a single
  person consumed a 100 of RDA for the 10 most
  important nutrients!
• Over 70 of people did not even meet 2/3rds of
  RDA for one or more nutrients.
• USDA National Food Consumption Survey 1977-78.
• USDA National Food Consumption Survey 1987-88.

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Source USDA 1994-96 CSFII
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Eat More Fruits Vegetables!
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Eat Fruits Vegetables!

• National Cancer Institute Eat 5-10 servings to
  prevent cancer!
• 90 of Americans eat less than 5 servings a day.
• U.S. average is 3.2 servings/day.
• Fruits vegetables contain vitamins, minerals,
  thousands of phytonutrients, dietary fiber and
  potassium.
• NHANES II data

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Are RDAs adequate?

• RDAs do not consider optimum intakes.
• Vitamin E 100-400 IU
• Vitamin C 200-500 mg
• Chromium 200 mcg
• Optimum RDAs are under development by the NRC
  Food and Nutrition Board (NRC FNB)

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Optimum Supplementation

• Ensures RDA levels
• Considers typical dietary intakes
• Optimum nutrient levels for long-term health
• Non-essential, beneficial nutrients

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What is LifePak?
LifePak is a comprehensive nutritional
supplementation program delivering the optimal
amounts of all essential vitamins, antioxidants,
minerals, and trace elements, as well as
beneficial phytonutrients.
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LifePak 5-in-1 Concept

• LifePak is FIVE formulas in one
• 1. high potency antioxidant formula
• 2. balanced B-vitamin formula
• 3. complete bone support formula
• 4. complete trace element supplement
• 5. phytonutrient formula

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LifePak Advantages

• LifePak is FIVE formulas in one
• 1. high potency antioxidant formula
• 2. balanced B-vitamin formula
• 3. complete bone support formula
• 4. complete trace element supplement
• 5. phytonutrient formula

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What are Free Radicals?

• Free radicals are highly reactive, short-lived
  compounds that can destroy the bodys fats,
  proteins and nucleic acids (DNA).
• Free radicals are involved in the etiology of
• cardiovascular disease
• cancer
• cataract, macular degeneration
• aging process

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What are Free Radicals?

• There are many types of free radicals...
• HO hydroxyl radical, 10-9 seconds
• RO alkoxyl radical, 10-6 seconds
• ROO peroxyl radical, 7 seconds
• NO nitric oxide radical, 1-10 seconds
• O2- superoxide anion radical, enzymic
• and reactive oxygen species (ROS)
• 1O2 singlet oxygen, 10-5 seconds
• ONOO- peroxinitrite, 0.05-1 seconds
• H2O2 hydrogen peroxide, enzymic

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Free Radical Sources

• Environmental pollution
• Radiation UV light, X-ray, g-ray
• Smoking 1016 free radicals/cigarette
• Normal oxidative metabolism of carbohydrates,
  fats proteins for energy production.

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Antioxidants

• Capture/neutralize free radicals
• (e.g., vitamin E in cell membranes, etc.)
• Intrinsic Antioxidants
• albumin, uric acid, a-ox enzymes (GPX, SOD,
  catalase), and others.
• Extrinsic (Dietary) Antioxidants
• a-ox vitamins, trace element cofactors,
  carotenoids, flavonoids, and others.

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Antioxidant Effects

• Decrease free radical damage (oxidation)
• especially in people with high oxidative stress
• smokers, elderly, people in polluted urban areas
• Improve cardiovascular health
• Reduce LDL-Oxidation atherosclerosis
• Slow down aging process
• Less DNA protein damage
• Help prevent cancer
• Protect DNA promote normal cell growth

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Antioxidants

• Many types of antioxidants must work together (in
  synergy) to afford effective protection from free
  radical damage.
• Antioxidant defense system

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LifePak Antioxidants

• Vitamin C, 500 mg
• Vitamin E, 300 IU, natural
• Selenium, Zinc, Copper, Manganese
• alpha-Lipoic acid
• Phytonutrients
• Carotenoids
• Flavonoids

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Objective of LifePak Studies

• Does LifePak supplementation improve antioxidant
  status and decrease LDL-oxidation in healthy
  non-smokers consuming typical U.S. diets?

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LifePak Antioxidant Studies

• Two double-blind studies (FDA-GCP)
• 140-subject parallel design (Houston, TX)
• 46-subject cross-over design (Evansville, IN)
• LifePak or placebo for 6 weeks
• Both studies evaluated antioxidant status and LDL
  oxidizability.
• FASEB J. 13(4) A546 (cross-over study)
• other publications forthcoming.

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LifePak Antioxidant Studies

• Inclusion/Exclusion Criteria for Subjects
• healthy non-smokers
• men women, ages 18-65
• on typical U.S. Diets lt 5 servings of fruits
  vegetables per day
• no other dietary supplements or medications

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Serum b-Carotene(nmol/L)
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Serum a-Carotene(nmol/L)
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Serum Vitamin C(mmol/L)
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Serum Vitamin E (mmol/L)
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Serum Selenium (mmol/L)
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LDL Oxidation

• LDL are prone to oxidation by free radicals.
• Oxidized LDL tend to adhere to artery walls more
  than non-oxidized LDL.
• Antioxidants can improve LDLs resistance against
  free-radical oxidation

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LDL Oxidizability
Blood Sample
Plasma
LDL isolation
Copper Ion Solution
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LDL Oxidizability
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LDL Oxidizability, lag time(min)
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LDL Oxidizability, Rate(mmol/min x g protein)
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LP Studies Conclusions

• LifePak improved antioxidant status.
• LifePak increased LDLs resistance against
  free-radical oxidation, and thus, may have
  cardiovascular benefits.
• LifePak is safe and well-tolerated.

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LifePak Advantages

• LifePak is FIVE formulas in one
• 1. high potency antioxidant formula
• 2. balanced B-vitamin formula
• 3. complete bone support formula
• 4. complete trace element supplement
• 5. phytonutrient formula

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LifePak B-Vitamins

• Balanced accdg. to optimum requirements.
• Optimum amounts for normal homocysteine
  metabolism.
• Homocysteine Undesirable amino acid by-product
  from methionine metabolism
• impairs vascular function, atherogenic
• independent risk factor for cardiovascular
  disease
• B12, Folate B6 help control homocysteine.

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LifePak B-Vitamins

• Regular LifePak B-Vitamins
• Thiamin (vitamin B1) 3 mg 200 DV
• Riboflavin (vitamin B2) 3.4 mg 200 DV
• Niacin 40 mg 200 DV
• Vitamin B6 (pyridoxine) 10 mg 500 DV
• Folic Acid 600 mcg 150 DV
• Vitamin B12 30 mcg 500 DV
• Pantothenic Acid 30 mg 300 DV
• Biotin 300 mcg 100 DV

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LifePak Advantages

• LifePak is FIVE formulas in one
• 1. high potency antioxidant formula
• 2. balanced B-vitamin formula
• 3. complete bone support formula
• 4. complete trace element supplement
• 5. phytonutrient formula

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Bone Nutrition Calcium

• Calcium (Ca) is the major bone mineral, and it
  helps prevent osteoporosis.
• Calcium intake 55 of men and 78 of women do
  not meet the RDA!
• Calcium RDA RDI (DV) 1,000 mg/day
• 1 gl. of milk 300 mg calcium 30 DV
• LifePak has 500 mg Ca 50 DV

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Bone Nutrition

• Calcium alone is not the answer!

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LifePak Bone Nutrients

• Magnesium Like Ca, a structural component
• 60 of bodys Mg is in bone
• Mg supplementation increases BMD
• Mg also promotes heart rhythm, blood pressure and
  muscle function (ATP action).
• Mg intake 66 of men and 76 of women do not
  meet the RDA!
• LifePak 250 mg Mg 62.5 DV

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LifePak Bone Nutrients

• Vitamin D Fat-soluble vitamin
• helps regulate Ca, Mg, and bone metabolism
• functions as a hormone
• Deficiency is common
• Experts recommend supplementation with 400 IU
  daily from multivitamins
• All LifePaks have 400 IU vitamin D

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LifePak Bone Nutrients

• Vitamin K Fat-soluble vitamin
• promotes Ca incorporation into bone
• Boron and Silicon trace elements
• support normal bone metabolism
• Soy Isoflavones (Phytoestrogens)
• promote bone mineralization

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LifePak Bone Nutrients

• Calcium 500 mg 50 DV
• Magnesium 250 mg 62.5 DV
• Vitamin D 400 IU 100 DV
• Vitamin K 40 mcg 50 DV
• Boron 3 mg n/a
• Silicon 3 mg n/a
• Soy Isoflavones 10 mg n/a

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LifePak Advantages

• LifePak is FIVE formulas in one
• 1. high potency antioxidant formula
• 2. balanced B-vitamin formula
• 3. complete bone support formula
• 4. complete trace element supplement
• 5. phytonutrient formula

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LifePak Trace Elements

• Key Features
• Highly bioavailable (utilized by the body)
• Excellent tolerance
• Complete spectrum at optimum amounts

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LifePak TraceElements

• Top Quality Sources (Amino Acid Chelates, Albion
  Labs, etc.)
• Zinc AA Chelate
• Iron AA Chelate
• Copper AA Chelate
• Iodine (iodide)
• Vanadium (sulfate)
• Selenium (SeMet, selenite)

• Chromium AA Chelate
• Manganese AA Chelate
• Molybdenum AA Chelate
• Silicon (metasilicate)
• Boron (citrate)

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LifePak Trace Elements

• Highlights
• Chromium (200 mcg)
• normal insulin and blood glucose levels
• 90 of US diets may be low in chromium
• effective in non-insulin-dependent diabetes
• Selenium (100 mcg)
• essential cofactor for glutathione peroxidase, an
  antioxidant enzyme
• may prevent prostate cancer

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Chelates Bioavailability

• Bioavailability the bodys ability to utilize a
  nutrient absorption tissue uptake metabolic
  functions.
• Amino acid chelates tend to have the highest
  bioavailability and solubility of all mineral
  forms.
• Amino acid chelates are often better tolerated
  than inorganic mineral salts.

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Chelates Bioavailability

• Chelates ? Amino Acid Chelates
• Pseudo-chelates mixtures of mineral salts and
  hydrolyzed proteins proteinates etc.
• LifePak covalently-bound, fully reacted amino
  acid chelates (Albion Laboratories)

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LifePak Advantages

• LifePak is FIVE formulas in one
• 1. high potency antioxidant formula
• 2. balanced B-vitamin formula
• 3. complete bone support formula
• 4. complete trace element supplement
• 5. phytonutrient formula

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Phytonutrients

• A.k.a. phytochemicals or secondary plant
  metabolites.
• Non-essential plant compounds with health
  benefits.
• Over 12,000 phytonutrients have been isolated
  from foods.

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LifePak Phytonutrients

• LifePak provides a broad spectrum of
• Carotenoids
• Flavonoids (Polyphenols)

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LifePak Phytonutrients

• Carotenoids
• over 600 carotenoids present in nature
• safe vitamin A sources (a- b-carotene)
• fat-soluble antioxidants (1O2 quenchers)
• promote immune function (b-carotene)
• prevent prostate cancer (lycopene)
• prevent macular degeneration (lutein)

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Phytonutrients

• Beta-Carotene Friend or Foe?
• high-dose (20-30 mg) synthetic beta-carotene may
  promote existing lung tumors (ATBC study, CARET
  study).
• Population studies beta-carotene decreases risk
  for most cancers, incl. lung cancer.
• Other carotenoids have been ignored in research.
  Most are more potent antioxidants.

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Phytonutrients

• Beta-Carotene Friend or Foe?
• Recommendations
• Eat more fruits vegetables!
• Pharmanex - IDN position Supplementation is
  beneficial
• with a broad spectrum of dietary carotenoids
• at physiologic levels
• reflecting carotenoids from fruits vegetables

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LifePakPhytonutrients

• LifePak Carotenoids
• beta-Carotene (D.salina) 6 mg (10,000 IU)
• lutein (Marigold extract) 2 mg
• lycopene (Tomato extract) 1 mg
• alpha-Carotene 2 mg
• Zeaxanthin
• beta-Cryptoxanthin
• (extracts conform to Pharmanex 6S Process)

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LifePak Phytonutrients

• Flavonoids
• over 5,000 flavonoids known in nature, 600
  present in our diets.
• water/alcohol soluble plant products
• powerful antioxidants
• many enhance microcirculation (blood flow)
• many appear to prevent cancer (epidemiological,
  animal studies)

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LifePak Phytonutrients

• LifePak Flavonoids (145 mg total)
• From 5 well-researched stdzd. extracts
• OPC from grape seed extract
• Hesperidin Naringenin from citrus extract
• Quercetin
• Isoflavones (genistein, etc.) from soy extract
• Curcumin (polyphenols) from turmeric extract
• Amount ? 5-10 servings of fruits veggies
• All extracts conform to 6S Process

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Synopsis Health Benefits

• LifePak optimum supplementation for
• addressing common nutrient deficiencies
• bone nutrition
• cardiovascular health
• glucose and insulin metabolism
• immune function

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LifePak Cardiovascular Health

• Antioxidants lower LDL-oxidizability
• Calcium Magnesium maintain normal blood
  pressure heart rhythm
• B-Vitamins maintain normal blood homocysteine
• Flavonoids promote normal platelet aggregation
  and blood microcirculation

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LifePak Insulin/Glucose Metabolism

• Vitamin C, 500 mg
• promotes normal sorbitol metabolism
• Vitamin E, 300 IU
• promotes normal platelet aggregation
• keeps protein glycosylation in balance
• Chromium, 200 mcg
• essential for normal insulin function

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LifePak Immune Function

• Promoting normal immune function
• Vitamins C E
• promotes cell-mediated specific and
  non-specific immunity
• beta-Carotene, carotenoids
• promotes natural killer cell activity
• Vitamin A, vitamin B6 zinc
• essential for immune function

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LifePak Women
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LifePak Women

• Young, Pre-Menopausal Women
• Key Features
• Bone Nutrition 1,000 mg calcium 500 mg
  magnesium (2x LifePak!), extra silicon
• National Insitutes of Health 1,000 - 1,500 mg
  Ca/day
• About 80 of young women do not meet RDA (1,000
  mg)
• FDA Health Claim Calcium prevents osteoporosis
• Extra Iron 10 mg, amino acid chelate
• iron deficiency is more common in young women
  over 70 do not meet RDA!

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LifePak Women

• Key Features, continued
• Folate and Inositol For women in their
  child-bearing years
• Folate prevents neural tube defects (FDA health
  claim)
• Extra Vitamin B6 20 mg
• 65 of women dont meet the RDA for vitamin B6
• Special Phytonutrients
• 25 mg soy isoflavones same as in 25 grams soy
  protein
• gamma-linolenic acid-rich oils.

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LifePak Prime
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LifePak Prime

• For Post-Menopausal Women Men Over Age 40
• Key Features
• Bone Nutrition 1,000 mg calcium 500 mg
  magnesium (2x LifePak!), extra silicon
• NIH 1,000 - 1,500 mg calcium per day
• Extra Zinc 20 mg amino acid chelate
• zinc promotes healthy immune function
• over 85 of the elderly do not meet the RDA

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LifePak Prime

• Key Features, continued
• Glucosamine 200 mg
• promotes joint structure function
• 200 mg doubles average dietary intake
• Special Antioxidants glutathione,
  N-acetyl-cysteine, coenzyme Q10
• Extra Phytonutrients More curcumin, grape seed
  OPCs added stdzd. Ginkgo extract and Milk
  Thistle extract.

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LifePak PreNatal
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LifePak PreNatal

• For Pregnant Lactating Women
• Key Features
• Optimum Antioxidants 150 IU natural vitamin E
  300 mg buffered vitamin C
• may prevent pre-eclampsia (gestational
  hypertension)
• pre-eclampsia affects 5-15 of pregnant women
• Bone Nutrition 650 mg Calcium 350 mg
  Magnesium
• pregnancy fetal bone growth
• lactation milk production

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LifePak PreNatal

• Key Features, continued
• Folate and Inositol 800 mcg, 500 mg
• prevent neural tube defects
• Extra Iron 30 mg, Amino Acid Chelate
• best tolerated and most bioavailable form of iron
• higher demands due to fetal blood muscle
  formation
• high risk for iron deficiency anemia
• Chromium 180 mcg, Amino Acid Chelate
• promotes normal insulin and blood glucose
  metabolism
• benefits in gestational diabetes mellitus

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LifePak PreNatal

• Key Features, continued
• Vitamin A 5,000 IU is safe and effective
• Supplementation with more than 10,000 IU of
  preformed vitamin A may increase the risk for
  fetal damage (teratogenic effects).
• Carotenoids Natural beta-carotene (5,000 IU),
  alpha-carotene, lutein lycopene.

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LifePak TeenTM

• Optimum Supplementation for 9-18 year olds

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THE PROBLEM Over 60 of teen boys and over 80
of girls dont meet the RDA for calcium or
magnesium USDA CSFII 1994-96 Survey Data
THE SOLUTION LifePak Teen Bone Nutrients 500
mg Calcium 200 mg Magnesium 400 IU Vitamin D 40
mcg Vitamin K 3 mg Boron 3 mg Silicon
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THE SOLUTION LifePak Teen Antioxidants 5,000 IU
Vitamin A 3 mg b-carotene 100 IU Vitamin E 200 mg
Vitamin C 70 mcg Selenium
THE PROBLEM Not enough antioxidant vitamins
Over 60 of teens dont get the RDA for vitamins
A E USDA CSFII 1994-96 Survey Data
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THE PROBLEM Not enough iron 72.5 of girls
ages 12-19 dont meet the RDA for iron USDA
CSFII 1994-96 Survey Data
THE SOLUTION LifePak Teen 9 mg iron as amino
acid chelate 50 of Daily Value
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THE PROBLEM Not enough zinc Over 65 of teens
dont meet the RDA for zinc USDA CSFII 1994-96
Survey Data
THE SOLUTION LifePak Teen 15 mg zinc as amino
acid chelate 100 of Daily Value
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LifePak Safety

• All vitamin mineral levels are below the NOAEL
  (No Observed Adverse Effect Level) established by
  the CRN (Council for Responsible Nutrition,
  1998).
• Phytonutrients are added at levels that are
  documented safe.
• Clinical studies showed no adverse effects to
  LifePak

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LifePak Directions

• One packet twice daily with meals
• meals enhance absorption (vitamins) and improve
  tolerance (minerals)
• twice daily promotes steady nutrient delivery,
  e.g., plasma levels of vitamin B6

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LifePak Precautions

• Pregnant lactating women, diabetics,
  hypoglycemics, and people with known medical
  conditions should consult with a physician before
  taking supplements

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LifePak Substantiation

• Over 1,000 peer-reviewed scientific papers on
  file documenting the efficacy and safety of all
  nutrients in LifePak.

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LifePak Substantiation

• No other complete multi-nutrient supplement has
  ever been subjected to two well-designed
  double-blind clinical studies to show antioxidant
  effects in healthy people.

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In other words...

• LifePak is the best multivitamin/mineral
  supplement -- worldwide!