Chem150 - Survey of Biochemistry

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Chem150 - Survey of Biochemistry

• Introduction

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Introduction

• The chemistry we will focus on this semester
• Organic Chemistry
• The chemistry of carbon
• Functional groups
• Biochemistry
• The chemistry of living systems

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Organic Chemistry
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Organic Chemistry

• Hydrocarbons represent the starting point
• Contain only carbon and hydrogen
• Groups include Alkanes, alkenes and alkynes

Butane
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Organic Chemistry

• Organic molecule are organized into functional
  groups
• Many contain elements other than carbon and
  hydrogen
• Oxygen
• Nitrogen
• Sulfur
• Halogens (F, Cl, Br, I)

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Organic Chemistry
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Organic Chemistry

• Functional Groups
• Hydroxyl groups (alcohols)

Hydroxyl Group
1-Butanol
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Organic Chemistry

• Functional Groups
• Amino groups (amines)

Amino Group
1-Butylamine
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Organic Chemistry

• Functional Groups
• Carbonyl groups (aldehydes and ketones)

Aldehyde Group
Butanal
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Organic Chemistry

• Functional Groups
• Carboxyl groups (carboxylic acids)

Carboxyl Group
Butanoic acid
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Organic Chemistry

• Functional Groups
• Functional group affect the physical and chemical
  properties of organic molecules.

Butane (alkane)
Butanol (alcohol)
Butylamine (amine)
Butanoic acid (carboxylic acid)
water
Butanal (aldehyde)
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Organic Chemistry

• Functional Groups
• chemical structure affects drug or
  hormone-receptor interactions

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Organic Chemistry

• Functional Groups
• Is this even possible? Or this?

http//www.ftc.gov/opa/2004/04/040429canspam.shtm
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THC and designer drugs is there a case against
Spice or K2?
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THC and designer drugs
D 9 tetrahydrocannabinol
Anandamide
JWH-018 ?
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ORGANIC MOLECULE IN THE NEWS Bisphenol A
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Nalgene polycarbonates
What chemical questions would you want to have
answered to decide ?
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PHARMACOPHORE IN THE NEWS Bisphenol A
http//e.hormone.tulane.edu/learning/estrogens.htm
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Biochemistry

• Biological molecules
• Amino acids and Proteins
• Carbohydrates and Polysaccharides
• Nucleotides and Nucleic acids
• Lipids (Fats, oils)

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Biochemistry

• Biological molecules
• Amino acids and Proteins

Carboxylic Acid Group
Amino Group
Alanine
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Biochemistry

• Biological molecules
• Carbohydrates and Polysaccharides

Glucose
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Biochemistry

• Biological molecules
• Lipids (Fats, oils)

Triglyceride
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Biochemistry

• Biological Macromolecules
• Proteins, Polysaccharides and Nucleic Acids
• Metabolism
• Taking things apart
• Putting things together
• Obtaining and using energy
• Regulation of processes.