The Evolution of

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The Evolution of Cytochrome
P450 in Animals David R. Nelson
University of Tennessee Dept. of Molecular
Sciences Center of Excellence in Genomics and
Bioinformatics
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Drug Metabolism in
humans CYP3A4/3A5, CYP2D6, CYP2C9
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CYP2C19, CYP2E1, CYP1A2, CYP2A6 90-95
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Metazoan Genomes Sampler
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Halocynthia roretzi adult and larva
Cnidarian
Chordate
Porifera (sponges)
Suberites domuncula
plus hermit crab
leech (annelid worm)
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3 Clan
UPGMA tree of
4 Clan
Hydra P450s
2 Clan
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CYP21
11A1
11-Deoxycorticosterone
11B1
Corticosterone
CYP17
11B2
CYP17
Aldosterone
CYP21
CYP17
CYP17
11-Deoxdycortisol
11B1
CYP19
Cortisol
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CYP51
UPGMA tree of Amphioxus CYPs (not mito clan)
CYP7/39 Clan
CYP20
CYP26 Clan
CYP4 Clan
CYP3 Clan
CYP19
CYP2 Clan
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CYP27A1
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CYP2R1
CYP27B1
CYP24
active form
inactive
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CYP24
Neighbor-joining tree
of amphioxus mito clan P450s
CYP11
CYP27
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