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Perspective of

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Title: PowerPoint Author: Okumura Akihisa Last modified by: Created Date: 3/6/2006 8:51:56 PM – PowerPoint PPT presentation

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Title: Perspective of


1
Perspective of Periventricular Leukomalacia
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2
PVL?? PVL?????? PVL?????? PVL?????????
3
PVL?? PVL??????
4
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??????????2????????????????????????MRI??????239??
????????
????(GA?37?) 115? ???(GA?36?) 124?
9
??? 124?
????? 118? (95) ??????? 8? BBTL??
1 ?????? (SCL or SCLPVL) 4
BBTL??/???? 1 MCE 2 ??????
110? PHP 5 PVL 99 PHPPVL 6
????? 2? (2) ?????? 1 ???????? 1 ???
1? (1) ???? 3? (2)
10
??????????PVL???
PVL??
PVL
1989-1993
1994-1998
206
250
40 (16)
28 (10)
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11
PVL?????????????????????????27-32???????10??????
PVL????????4?????????????????????? PVL?????????
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12
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13
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PVL???? ????????????
21
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22
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?????????PVL????
?? I? II? III? IV/V?
n203 n25 n31 n27 n9
24
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25
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26
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27
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??????????
Disorganized pattern
AF3-C3 C3-O1 AF4-C4 C4-O2 AF3-T3 T3-O1 AF4-T4 T4-O
2
??????? ??????? ???brush
29
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30
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31
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32
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?????disorganized pattern??????????? ??????PVL??
????????????? ?????????????????????????????PVL???
? ???????????????PVL???????
33
PVL????????
34
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PVL????????
36
PVL????????
37
PVL????????
38
PVL????????
39
PVL????????
40
PVL????????
41
???PVL???????
ASA??????CSA?????
42
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43
PVL????????
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44
PVL????????
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45
??????PVL???????????????? ?????????PVL??????????
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PVL?????????????????????????
46
PVL??????????????
47
PVL??CO2??
48
PVL??CO2??
49
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PVL??CO2??
51
PVL??CO2??
52
PVL??CO2??
53
PVL??CO2??
54
PVL??CO2??
55
PVL??CO2??
56
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58
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PVL???????
60
PVL???????
61
PVL???????
62
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63
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64
PVL???????????
65
PVL???????????
SNAP Score for Neonatal Acute Physiology
??37????????24????????????????????????????0??????
????1??3??5??????????????????????????SNAP???????
66
PVL???????????
67
PVL???????????
68
PVL???????????
SNAP?????PVL?????????????????????????????????????
??????????????????????????? ??????????????????PVL
???????????????
69
PVL??????????
????????
?????????????????????????? ????????????????CO2??
????????? ??????????????????????Na????Kcreatinin
e?????????????????????????creatinine???????
???????????!
70
PVL????????
71
PVL??????
72
PVL??????
73
PVL??????
PVL????????APGAR score???? PVL?????????????? ??
???????????PVL?1??????? ?????????????PVL?????????
??PVL????????????????????????? PVL?????????CAM???
????????????????????
74
??????????? ???????????
75
?????????(PVL)?????????????????flip
flap???variability???????????(Okamura et al. Int
J Gynecol Obstet 1997.)
76
???
Excel????
???????????
77
??????
??????
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p lt 0.05
78
90 Frequency Edge
75 Frequency Edge
50 Frequency Edge
79
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80
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81
??????????????????????
PVL???????????????????????????????????? ????????
????????????????????????
82
PVL?????
83
PVL?endotoxin????
84
PVL?endotoxin????
85
PVL?endotoxin????
86
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87
PVL?????
??????
??????????????????????? PVL?????????????????????
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88
PVL?????
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???????????????PVL???????????????CAM???????? ??
???2???PVL???????????CAM????????PVL??????????????
?????
89
?????????
90
????hANPBNP?PVL
PVL???????????????????????????? ????????????????
????????????????????????? PVL???????????????flip
flop????????????Flip flop?????????????????????????
??????????? ????????????????????????
91
Study???
PVL???????????????????????? ????????????????????
???????????????????????
92
??
93
?????EPO?PVL
PVL??????????????????????????????? ?????????????
?????????????????? IUGR???????????????? PVL?????
??????????????????????EPO??????
94
EPO (mU/ml)
???
PVL
95
PVL???????????
PVL??????????????????????????????????ACE?????? P
VL??????????????????????????????????????????? ???
PVL???????????????????????????????????????????????
?MDA-LDL8-isoprostane????????????????
96
(ng/ml)
(IU/l)
ACE
P-?????
(U/l)
(pg/ml)
8-isoprostane
MDA-LDL
97
????PVL?????????????????????????????
98
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99
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100
Textbook Is
Not To Read
But To Revise
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