Your Main Point

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6 ???????????????
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Your Main Point

• Your Sub Point

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?? MHC H-2? MHC HLA
Jean Dausset 1916- Nobel Prize 1980
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6-1 MHC ????????????
MHC ???????
MHC-I
MHC- II
?????
a2
a1
b1
a1
Ig???
a3
b2
b2m
a2
????
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MHC??????? I?II?MHC?????? a ? ?? b
?????????a ???????,MHC-I? b ?????? b2m,II???? b
??????????????MHC???????????,Ig?????????
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MHC-I? MHC-II????? MHC-Ia ?? a1 ?
a2????????????,a3 ???????,b2m????????
MHC-II?????????? a ? b ?? a1? b1 ???????????????
a ???????????????,????? b ????????? a1 (?? MHC-I
?II),?????? a2 (I ???) ? b1 ?? (II???)?
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MHC ???????
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HLA ?? I ?A,B,C,E,G(b2m) II?DR,DP,DQ DRa,DRb,
DQa,DQb,DPa,DPb
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HLA?????? ????????HLA-Ba ???????????,???????
?????N??180????????,????????MHC????????
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6-2 ?MHC?????
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?MHC ??????? ?MHC??????????????,????????
???????????DNA????MHC???????I?II???????????HLA-I?H
LA-II????III?????????????????
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HLA ???I?
8 ? MHC-I ??,?HLA-A?-B?-C?-E?-F?-G?MIC-A
?MIC-B,??????????????? HLA-A?B ? C ????I ?
MHC??,?? MHC-Ia ?????????????,????????????????? H
LA-E?-G ? -F ????? MHC ??,?? MHC-Ib ???
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HLA???II?
??9????????,?? HLA-DP?DN?DM(DO)?DQ ? DR ?5
?????,?????? A ? B ?????,???? HLA-IIa ? b
?? ?????HLA-D???MHC-II a ? b ??????MHC-II??,?????
a ? b ??????
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HLA-DR ????????DRA ? 2-5 ?DRB ???,?? DRB
???????????????HLA-DR???? DRB1? DRB3?DRB4 ? DRB5
?????,DRB9 ???????,DRB2,DRB6,DRB7,DRB8
????(pseudogene)?
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???HLA-DR??? ??DRB?????????9?,????????DRB???
???????DRB??????????????HLA DR????????????????DRB?
???
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HLA-DP??????DPA1?DPB1??????,???? DPa ? DPb
?? DQA1?DQB1?????,????HLA-DQa ?DQb ?? DMA ? DMB
???????? a ? b ?,?MHC-II???????????????????? LMP-
2 ? LMP-7 ???????????(proteasome)?????,TAP-1 ?
TAP-2 ??????(transporter in antigen
processing,TAP)?
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HLA???III?
????????????????,???C4?C2?B????TNF-a
?TNF-b(????)?????????????(????????????????)?????MH
C??????
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HLA??????
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HLA?????? HLA-A,-B?-C???????59?118?36???????
HLA-DRB1?DQA1? DQB1?DPB1?DPA1???????168?19?30?73?8
????????????????????4?????????????????(?DRB30201-
0205)????????????????????????????
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HLA??????
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HLA???????
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6-3 MHC??????????
?????

??????
MHC?????????
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?????? MHC-I??????MHC-Ia?? a1?
a2?????,?MHC-II??????MHC-IIa ?? a1?MHC-IIb ??
b1????????????????,????????????MHC-I??????9?,?MHC-
II????????????
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6-4 ???
C00H
NH2
???
??
????
MHC-II??
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????MHC????? MHC-II?????????????????(c)?????
?N?C?????????,???????????????????????,???????MHC
-II????????
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MHC-I
? ? ? ? ?
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????MHC????? MHC-I????????????????(a)??????(b)?
??????6???(?A?B?C?D?E?F??),???(??)???2?3?6?7?9???
??????????B?D?C?E?F??,??1?4?5?8???????????(?TCR??)
?N????1????????A?????
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MHC?????????
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6-5 ???????????
?????????

?????????
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????????? ???????????????????????????,??TAP??
??????????????????MHC-Ia ?b2m??????????????????CD8
?T?????TCR?CD8????MHC-I/????????
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MHC-I ???????? (class I antigen presentation
pathway)
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MHC-II ? ? ? ? ? ? ? ? ?
? ? ?
CD4 T ??
CD4
TCR
CD28
???
B7
5
APC
?????
2

4
a,b????????
???
3
???
1
MHC-II?????
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??????? ?????????MHC-IIa ? b ??????????
??????(APC)??????????????,??????????????,?????????
??????????????????MHC-II???????,????????????MHC-II
????,??????????????CD4?T?????TCR?CD4????MHC-II/??
??????
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MHC-II ?????? (class II antigen presentation
pathway)