Murein Biosynthesis Tutorial

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Murein Biosynthesis Tutorial
by
Willie Claiborne Brown, Ph.D. Professor
Emeritus University of California, San
Diego January, 2001
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Legend
Uridine Diphosphate-N-Acetyl Glucosamine
Uridine Diphosphate-N-Acetylmuramic Acid
L-Alanine
D-Glutamic Acid
Dibasic Amino Acid
D-Alanine
D-Alanine
Tri-Alanine Peptide
Bactoprenol
Carrier Lipid-Derivative of a C-55 Polyisoprenoid
Alcohol
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Formation of Amino Sugars
Fructose-6-P
Glutamine(NH2)
Acetyl CoA
N-Acetylglucosamine(NAG)
UTP
P
Phosphoenol Pyruvate(Lactyl)
Reduction Steps
Other Cell Reactions
Murein Biosynthesis
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Sequence of Events inMurein Biosynthesis
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D-ala-D-ala
5
L-ala
ATP
Cytoplasm
Alanine Branch
7
ATP
ATP
2-4
ATP
ATP
UDP
1
P
UMP
9
P
8
13
Membrane
10
Section of Growing Murein
11
12
14
Crosslinking Step
Exterior
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Sequence of Events inMurein Biosynthesis
6
5
ATP
Cytoplasm
Alanine Branch
7
ATP
ATP
2-4
ATP
ATP
UDP
1
P
UMP
9
8
13
Membrane
10
11
12
14
Exterior
Crosslinking Step