Genetics

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Genetics
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Definitions

• DNA
• Chromosome
• Allele
• Loci
• Mitosis
• Meiosos
• Genotype
• Phenotype
• Karyotype

• Heterozygous
• Homozygous
• Dominant
• Recessive
• Incomplete dominance
• Co-Dominance
• Sex-Linked
• Congenital Defects
• Teratogen

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Mammalian Cell
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DNA and Chromosomes
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Chromosome Segment / Gene
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Gene Segment / DNA
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Histones and Nucleosomes
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One Gene One Polypeptide
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Transcription and Translation
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Chromosome Arm Structure
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Autosome Chromosomes
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Sex Chromosomes and Structure
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Chromosome Types and Number
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Organisms Chromosome

• Species.doc

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One chromosome, 2 sister chromatids
Karyotype at Metaphase Stage
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Loci of Genes
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Human Chromosomes
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Karyotyping
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Human Chromatids Stained
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Chromosome Replication
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Homologous Chromosomes
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Homologous vs. Hemizygous
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Cell Cycle
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Mitosis Models
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Mitosis Histology
prophase
metaphase
Metaphase/anaphase
anaphase
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Meiosis Models
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Meiosis Crossing Over
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Karyotyping

• Karyotpype at Metaphase stage of the cells
  chromosomes
• Arranged in pairs
• Sorted by
• Size
• Centromere position
• Metacentric
• Subcentric
• acrocentric
• Stain to create bands

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Gene Mapping
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Chromosome Banding
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Inheritance Patterns

• Dominant / Recessive
• Dominant Trait expressed
• Recessive trait only in homozygous state
• Co-Dominant
• Both traits expressed
• Incomplete Dominance
• Partial expression
• Sex-Linked

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Dominant / Recessive Cross
Heterozygous cross
Homozygous cross
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Co-Dominant Cross
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Incomplete Dominance Cross
Sickle Cell carrier Parent Partial sickling
S
s
Sickle cell Parent All cells sickle
Ss Sickle cell carrier ss Sickle cell offspring
Ss Sickle cell carrier
s
ss Sickle cell offspring
s
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Chromosome Abnormalities
Normal
Deletion and Transposition
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Mutations
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Translocation
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CF
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Sickle Cell Anemia
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Alzheimers Disease
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Polydactylia
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Chromosomes 1, 2, 3
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Chromosome 1-4 diseases
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Chromosome 5 8 Diseases
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Chromosome 9 12 Diseases
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Chromosome 13 16 Diseases
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Chromosome 17 20 Diseases
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Chromosome 21, 22, X, Y Diseases
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X- linked chromosome Diseases
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Sex Linked Cross
Colorblindness
X linked trait
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Chromosome X, Y Diseases
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Sex Linked Chromosome Problems
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Karyotype of Sex Linked Problems
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Diagnostic Tests
DNASeq.Process.pdf
PCR
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http//gslc.genetics.utah.edu
http//www.ornl.gov/sci/techresources/Human_Genome
/home.shtml
Human Genome Project