Title: ????????(MLA)????????????????????????
1 ????????????? ??????????????? ???
2 ????????(MLA)????????????????????????
3? ? ? ? ? ? ? ?
- ????????
???????????12-16??????????????? - ?????????????,??????
4? ? ? ? ? ? ? ?
- 14?????????????
- ???????
- 15??????
- 16?????????????
- ??????????
5? ? ? ? ? ? ? ?
- ????,???????G????????????????
- ?????????
- ??????????,???????????
- ????????,????????????
6? ? ? ? ? ? ? ?
- 5. ??????????
- 6. ????????????
- 7. ????????
- 8. ???,??????????????
7? ? ? ? ? ? ? ?
- ?????gt?????,?????????????,????
- ???????????????????????????
- ??????????????????????,??????????????????
- ??????,?DPB(?????????)?????
8 ???(EM)?1958???????,40?????????????????
1985???????????(RTM)?????(AZM)?????(CTM)????
?(DTM)?????(FTM)?EM????,???????????????
9?????????
- ???????,?????
- ???????,?????
- ??????,???????
- ???????????????????,????????????
10?????????????????
- ? ? ??(mg) ???( mg/l) ????(h) ?????
(h) - ??? 500 0.3-2
1.2 1.6 - ???? 400 2.1
1.7 4.7 - ???? 300 9.1-10.8
1.6 11.9 - ???? 500 0.4-0.45
2.0 41.0 - ???? 500 1.2-0.45
1-2 8.0 - ???? 500 0.29
4.0 20-50
11?????????
- ????
- 14??????????????
- ?????
- ???????
12?????????
- ????
- 15??????????????
- ?G-??????????
- ????????????????
- ???4???
- ????????????????
- ??????
- ?????3548??
- ?????????????????
13?????????
- ????
- 14??????????????
- ?G????????????????
- ?????
- ???????????????????
- ?????????
- ?????????????,?????
- ????
14 CTM
AZM ?????
??? ?????
??? ???
?????
????? ???
????? ??????
????
????
15- ???????
- AZM??????????????????????????????????????????????
??? - Tribble????,??????AZM????1.0g,????0.5g/d,?6?,???10
0?
16???? ?????AIDS??????? 3-40?Cacassin?CTM???
??????????????? ?,?CSF??????????
17- ??????
- ????????????????????????,???????????????,?????????
??????????????????? - 1991?Lee???CTM?RTM?????
- ????????????????????
- CTM?RFP?????,CTM????????????????????????????
18??????? ??????????L???,CTM?AZM?EMB??????? AZM?RT
M?INH?RFP??????, ??????????????????????????
19????? EM????????????,???gt3?? ??,AZM?????????????
? 1)??0.5g/d??,0.25g/d?4?,
10-14????????? 2)0.5g/d?3?,??10?,????????
RTM0.5-1.0g/d 5-7? CTM1.0g/d ???????
20????? ???(Mycoplasma)??????????? ???
?????(M.pneumoniae)
????? ?????(M.hominis)
?????????????????
?????(M.ureaplasma)
??????????????????
21????? ???(chlamydia)????????????
?????(1998?????TWAR) ??????(???????????) ?
?????????????????AIDS? ???????????
22?????(chlamydia trachomatic)
??????????????????? ??????????
?? ?????????????,???55.8
23??????????? ?????,???(EM)??????????????????
?????
24 1.??????????????? 1984????????DPB??????,
????? 1)EM???????????????,??????
??? 2)??????? ???????
????? ???????????????? ??????
3)?????????? 4)??????? ???????
????
25????? ??????????????? ????????????
262. ????????? 1986?,Tomo
mosa???EM????? ??????? ???????????????
27?????????? Janssens?EM?? 1
???????? ??,???????????????? ??? ???30??
0.25g tid Po 4?1??
28?????? EM????????, ??????????????
29???? ???????????????? Fiorucei??,???????????? E
M ????? ??????
?????????????
30??????? 1990???EM ??????????
???? ,???????????? 0.25g q6h
??8?, ???????
313.??????(PE) ???????????????, ???????????
,?????????,????,?????????????????
324.?? ?????????, ???????????? 1g/d??,????2-6? ?
1g?5??100ml ??2-3 ????
335.??? ??????????EM 0.3 tid, ???4??3?,????2??
??
346.?????????? ??????????????????, 1989?Hof
sli????,??EM?????? ?????P-???
???????? ?? ??????????
???? ????????