Image-Guided Interventions; Ultrasound

1
Image-Guided Interventions Ultrasound

• Group Members
• Mehrdad Negahban (Eng. Mechs., UNL)
• Jiashi Yang (Eng. Mechs., UNL)
• Jason MacTaggart (Surgery, UNMC)
• George Gogos (Mech. Eng., UNL)
• Mehmet Can Vuran (Comp. Sci. Eng., UNL)
• Feng Xie (Internal Med., UNMC)
• Dong Wang (Pharm. Sci., UNMC)
• Greg Bashford (Bio. Syst. Eng., UNL)
• Joe Turner (Eng. Mechs., UNL)

2
Charge

• Your task is to develop core ideas/projects for
  an 8-10M (1.25-1.5M per year for 5 years) NIH
  Center proposal.
• Catheter-based Ultrasound with Microbubbles
• Specifically, you should consider the following
  questions

3
Briefly describe the core projects your group
would design for the Center. Please dream big.

• Intravascular Ultrasound with Targeted
  Microbubbles
• Microbubble enhanced ultrasound is normally done
  only in regions where ultrasound imaging can be
  done
• Project Focus
• Use intravascular ultrasound (IVUS) with focused
  beam profile to burst microbubbles in areas of
  the body where ultrasonic imaging is not possible
• Introduce drug-laden microbubbles for targeted
  drug delivery
• Diagnose delivery amount using IVUS-based
  targeted tissue palpitation

4
Identify the key faculty from from both campuses
to involve in these projects. Include their
strengths. (UNMC on next slide)

• UNL Faculty Strengths
• Joe Turner (ultrasonic modeling)
• Greg Bashford (ultrasonic imaging)
• George Gogos (fluid flow)
• Jiashi Yang (externally-guided bubbles/particles)
• Mehrdad Negahban (in-vivo tissue
  characterization)
• Li Tan (development of guidable particle)
• Mehmet Can Vuran (wireless particle movement)
• Sensor design expert

5
Identify the key faculty from from both campuses
to involve in these projects. Include their
strengths.

• UNMC Faculty Strengths
• Jason MacTaggart (vascular surgery)
• Feng Xie (ultrasound/microbubbles)
• David Holtzclaw (microfluidics)
• Surgical Oncologist
• Center for Nanomedicine Drug Delivery

6
Identify external academic partners expertise
or equipment resources/strengths that are needed
to accomplish these projects.
7
List potential industry/foundation partners
(think broadly) and what they would contribute.
Include reasons why they would be interested.
8
Describe how you would link the Center to other
campus resources.