Iat????? ?fa?

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Iat????? ?fa?µ???? t?? ?d??????? (medical
applications of hydrogels)

• ?a????a??? ?a??a
• S??F?
• ?p.?a????t??
• ??ss?? ?????a?p??

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???a ????a ??a ta p???µe?? ?????
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?? e??a? ? ?d??????

• ???t?? p???µe????? a??s?d?? ad????te? st? ?e??
  (IPNs)
• p.?
• PHEA (poly hydroxeythyl acrylate)

• ??ad????? p???µe???? d??t?a µe e?e???µe?? ßa?µ?
  ?d??f?????t?ta? ????? d?µ???????e? ap?
  p???µe??sµ? t?? µ???µe???? ?d????-a?????
  a??????? (hydroxyethyl acrylate)(HEA) µe
  d?af??et???? s???e?t??se?? a??a????? µ?sa se
  ????te?a p???µe??sµ??? p??? a?????-a???????.

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??µ??????a ?d???????

• ?d?????? S?st?µa f??t?sµ??? µe ?e??

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?p?s?? ?p??????

• ???a?????e? µ?-???sta????? ste?e? ????? p??
  ap?te????ta? ap? ??a ???? ???a????? f?s??
  pa??de?µ??a se µ?a d??????s? d??t???. ?? ????
  µp??e? ?a e??a? p.?. ???a????? d?a??t??, ??a
  ????t? pet???a?? ? f?t??? ??a?a. ? d?a??t?t?ta
  ?a? ?? d?ast?se?? t?? e??a? s?µa?t???
  ?a?a?t???st??? ??a t?? e?ast???? t??? ?d??t?te?.
  ???s? se
• f??µa?a, ?a????t???, s??t???s? ????? t?????,
  ?a??? ?a? t??f?µa.

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?p?s?? ?p??????

• ???????? (Xerogels)
• ?? xerogel e??a? ??a ste?e? p?? s??µat??eta?
  ap? ???? µe ???a?s? µe a?eµp?d?st? s???????s?.
  Xerogels s?????? d?at????? ????? p???de? (25)
  ?a? t?? te??st?a ep?f??e?a (150-900 m2 / g), µa??
  µe p??? µ???? µ??e??? p???? (1-10 nm).
• ? Te?µ??? epe?e??as?a e??? xerogel se ??????
  ?e?µ???as?e? µ?s? p???s?ss?µ?t?s?? (s???????s?
  t?? xerogel ?fe??eta? se µ?a µ???? p?s?t?ta ????
  ???d??? ) ??s?ast??? µetat??pe? t?? p???d? ?????
  se ??a p???? ??a??.
• ?e??????
• ?ta? ???eta? ?p? t?? ap?µ?????s? d?a??t??
  hypercritical (?pe????s?µ?? s???????), t? ???t??
  de? s????????eta? ?a? ??a e?a??et??? p???de?,
  ?aµ???? p????t?ta? ????? ???st? ?? ae??????
  pa???eta?.

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?a?a?t???st??? ?a? ?d??t?te??d???????

• S???? s??a?t?ta? ?? ?????e?d??(colloidal gel)
  ????.
• ?pe?ap????f?t??? (p?? µp??e? ?a pe????e? p??? ap?
  99wt ?e??) t?? f?s???? ? s???et???? p???µe???.
• ?d??f??? s?µpe??f???(???? desµ?? µe ?? ,-COOH
  ?.a )
• ??a??te? ??a ßa?µ? e?e????a? ?µ??? µe f?s??? ?st?
• ???s?µßat?
• ?e ???a ????? s??t??e?ta? d?µ?? µe e??? f?sµa
  µ????µ??f??????? ?a? ?d??t?t??.
• ????? µ??a???? a?t??? ( µ??a????? ?d??t?te?)
• ?e?t??s? µ??a????? ?d??t?t?? µe e?a??a?? t??
  ?d??f???? ?a? ?d??f?ß?? s?µpe??f????

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?e?t??s? µ??a????? ?d??t?t??

• ?e?t??s?
• ?e a???s? t?? p????t?ta? t?? sta???s??dedeµ????(cr
  oss linking) µ???µe???
• ?e s?µp???µe??sµ? µe ??a p?? a??e?t??? ?d??f?ß?
  s?st?µa
• ?e ???st????s?

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Teµe???de?? ??µ??

• ?d?????? ? s?st?µa p???µe???1
• ? ?e?? 2
• G G (p ,T, ?1)
• (Gibbs) ?1
  m1/(m1m2)
• p p?es?
• T ?e?µ???as?a
• ?1 ???sµa µ??a?

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?e??aµat???? pa?ad????

• wf(agel) µe ? sta?e??
• w pa?????ta? ?e?t???????t?ta? t?? ?e??? µ?sa
  st?? ?d??????
• ? ?e?µ???as?a
• agel s?et??? ???as?a

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?e??aµat???? pa?ad????

• ???sta????? p???µe?? ? ???sta????? ?µ??f?
  pe?????, ?f?stata? ep?s?? ? ?????a t??
  ?e?µ???as?a? ?a??d??? µet?pt?s?? Tg, ? ?p??a
  ep??e??eta? ap? t??? a????????? pa?????te?
• ?p? t? ßa?µ? ???st????s?? ????s? t?? ßa?µ??
  ???st????s?? ?d??e? se a???s? t?? Tg
• ?p? t?? e??aµ??a t?? ????a? a??s?da? ????s?
  t?? e??aµ??a? t?? p???µe????? a??s?da? ?d??e? se
  µe??s? t?? Tg
• ?p? t?? p??st???µe?e? ?µ?de? (e?d?? ?a? a???µ?)
  st?? ßas??? a??s?da
• ? p??s???? ?st? ?a? µ????? ?µ?da? st? ßas???
  a??s?da a????e? t?? Tg (S?. 15). ??????s? t??
  µ????? p?e?????? d?a???d?s?? ?d??e? se µe??s? t??
  Tg

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?at???? ???s? t?? ?d??p??t?µ?t??

• ???-?????(biomaterials) e??a? f?s??? ? te???t?
  ????? p?? µp????? ?a eµf?te????? se ?µß??
  ???a??sµ? ?a? ?a ep?d?????s??? ? ?a
  a?t??atast?s??? ?st?.gt µ?µ?s? t?? ?d??t?t?? t??
  ?st??
• ?pa?t?se??
• µ? t?????
• µ? ?a????????a
• sta?e??? ??µ???? ?d??t?te?
• ad?a??
• ?a µp??e? ?a ???e? ap?ste???s?

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???t?p???a?? a??pt??? s???et???? µat???

• ??s?? ??µ???? ?at?fe?a? ?a ?atas?e??s??? ??a
  µ??ad??? s???et??? a?????? t?? ?e??d??? s?µat??
  t?? µat???
• ?? ?e??de? s?µa e??a? µ?a d?afa??? ?e?at???d??
  ??s?a p?? ?a??pte? t?? ?????t?ta t?? µat??? ?a?
  ep?t??pe? st? f?? ?a ft?se? µ???? t??
  aµf?ß??st??e?d?.

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? ??s?.

• ?atas?e?? e??? ???? p???µe???? ,????G???S
• µe ?a?a?t???st???
• µe???? e?ast???t?ta
• ?e??e?t???t?ta se ?e?? p??? ap? 98 wt
• ?dat?d?a??t? p???µe??? p???ß?????p??????d???
  (PVP) ? ap? p???a????aµ?d??.
• ????a? t?? t??p? ?atas?e??? d?afa??? e?ast????
  sfa???? d?aµ?t??? 22-25 mm ??a t?? a?t??at?stas?
  t?? ß??ß?? t?? µat???.
• ????s? sfa???? se ?e?? ?????ta? a??ate? (????
  de??t? d????as??)µe ap?t??esµa ?a µ??
  ap????pteta?.
• G?a t?? e?sa???? t?? st?? ?????t?ta t?? µat???
  apa?te?ta? µ??? µ?a µ???? ?e????????? t?µ?.

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?p????? ta ??ast???tta?a ?a? ??a e?d??? Gel ?a
Te?ape?s??? ?a????????e? ???

• ß?ast???tta?a ?d?????? ? Te?ape?a ?a??se??
  ??t?a??? ??e??? (???).
• ??e??e?t?µata ?d???????
• s?st?µa µ?sa st? ?p??? ?? ?e????e? a?apt?ss??ta?
  e????a
• ?p?st????? se ad??aµa ??tta?a
• ?et?d?s? ??µ???? ??s???.
• ?e?????t?µa
• ?fa?µ??? p??? t? pa??? µ??? se ??a

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??p? ad??at?sµat?? ap? ?d??????

• ??s??s? ???esµ?? ??? ?a? 6 ??e?
• ?? µ????s??p??? ??p? e??a? se µ??f? s????? ?s?
  pa?aµ??e? ????, e?? ?ta? ??f?e? µe ??a p?t???
  ?e?? µetat??peta? µ?sa st? st?µ??? se sfa??a ap?
  ?e??.
• ?? ??p? pa???eta? ap? ??tta???? ?a? µp??e? ?a
  ap?ß???e? ap? t?? ???a??sµ?.

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????? st?? ??t?de? ..

• ??a e??s?µ? eµf?te?µa ??a t?? ap??at?stas?  t??
  ??t?d?? ?a? t?? eµßa???se?? t?? d??µat??.
• ?p?te?e?ta? ap?
• e??aµpta µ????s?µat?d?a a???????? ?d??????? ?a? 
  ?a?????????? ????? µ? ?????? p????e?s??.
• ?? e??s?µ? ????? eµf?te?eta? st? d??µa ??a ?a t?
  a?as???se? µe t? ß???e?a t?? ?d???????.
• ?a µ????s?µat?d?a t?? ?d??????? e??a? ?µ???µ??fa
  ?ata?eµ?µ??a µ?sa st? ?a????????? ??? ?a?
  pa?aµ????? st? s?µe??  t?? eµf?te?s??
•   ?p?t??esµa
• t? 40 t?? ?????? p?? ?a eµf?te??e? pa?aµ??e?
  st? d??µa. ?? ?a????????? ??? ap????f?ta? se
  ???e? eßd?µ?de? e?? ta s?µat?d?a t?? ?d???????
  e??a??sta?ta? st? d??µa ?a? d?e?e????? t??
  ???a??sµ? ?ste ?a pa???e? d??? t?? ????a????.

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????? ?a? st?? e??se?? ??s???????

• ?? p??t?p???a?? ??p? ??s??????? e??a? ft?a?µ???
  µe t?t??? t??p? ?ste ?a µetaf??e? µe asf??e?a t??
  ??µ??? st? ??te?? ?p?? ?a? ?a ap????f?ta? ap? t??
  ???a??sµ?.
• µe t? ß???e?a t?? ?a??te???????a? ?? ep?st?µ??e?
  d?µ??????sa? µ?a ?d?????? ??a e?d??? p???µe???
  ????? t? ?p??? pe??ß???e? t?? ??s?????? ? ?p??a
  p??state?e? t?? ??µ??? µ???? ?a ft?se? st?
  st?µ??? t?? as?e????.
• ? ?d?????? ap?te?e?ta? ap? µ???a??? a??s?de? p??
  ?at? t?? ????????s? t?? ta??d??? a??????? ?a?
  ep?t??p??? t? s?st? ap?d?sµe?s? t?? ??s???????.
• t? p???µe??? ????? ap?ß???eta? ap? t?? ???a??sµ?.

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HYDROGEL ACTIVE ??????????? ???T????? 

• ? e?e??? d??s? t?? Heltha hydrogel active
  ep?t?????e? µe??s? p???? ta?e?a ep????s?
  ????? ?????/s?µ?d?a ste??? pe??ß?????
  (eµp?d??e? t? µ????s?) ste?a?? p??stas?a t??
  p?????

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?e?? p??? ap??at?stas? f?a?µ???? ??ast??

• ap?te?esµat??? µ???d? ap??at?stas?? ??ast??
  s??d?sµ?? st? ???at?
• t? p??ß??µa ?s?? t??a ???e?
• fa??eta? ?t? ? ??a µ???d?? d??e? t? d??at?t?ta
  st? s??desµ? p?? ??e? ?p?ste? ???? ?a s????????e?
  ?a??.
• ?e??,p?? µp??e? ?a ?p??atast?se? t?? ???e???
  ?p?st??µat??.
• ?? ?e?? ap?te?e?ta? ap? ????a????-t? ßas???
  p??te??? t?? s??det???? ?st??-p??sµa a?µat??
  p???s?? se a?µ?pet???a ?a? ap? t?? ?e??µe??
  ?d??????

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Te?ape?a ??????

• H ???? ?a? ? ?d?????? ft????eta? ap?
  ??a"?e??e?d??" p???µe??? µe p??p????? ???????.
  ?e??????? pe??p?? 80 ?e??, e??a? e?d??? ??a t?
  ?e?ape?a ?e???t???? ?st?? ?a? p??????? t??
  a?t???t??? ?a?a??sµ?.

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Fa??? epaf??

• Fa??? s????????-?d??????? (SiH) ?? ?p????
  ep?t??p??? 5-8 f???? pe??ss?te?? d???e?s?
  ???????? st?? ?e?at?e?d? se s??s? µe t???
  s?µßat????? fa????.
• ?da????? ??a ?s??? a?t?µet?p????? p??ß??µata
  ????t?ta? st? pe??ß????? e??as?a? ? ????
  ep???a??? a??e?????.
• ??????s? µ??p???? sfa?µ?t?? ??? 25D

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??ß?????af?a

1. Gloria Gallero Ferrer Valencia,2001 Structures
   and properties of polymer hydrogels based on
   interpenetration of a hydrophilic and a
   hydrophobic network
2. vita.gr  http//www.sugarfree.gr/
3. www.iatrikionline.gr
4. http//search.medscape.com/all-search?queryTexthy
   drogel
5. http//www.dermaline.gr/articles.php?articleId196
   
6. http//optical-house.blogspot.com/
7. http//www.derma-gel.com/pdf/dggrec.pdf
8. http//www.iator.gr/
9. http//www.stivoz.com/