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?????????????? Penicillium

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... penicillin- bing ding protein PBP ... – PowerPoint PPT presentation

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Title: ?????????????? Penicillium


1
?????????????? Penicillium
2
Penicillium
  • ?????????????????????????????????????
  • ???????????????????????????????????????
  • ??????????????????????????????????

3
?????? Penicillium
4
???????????????
  • ?? ?.?.1929 Alexander Fleming
  • ????????? staphylococcus aureus
    ??????????????????????????????
  • ???????????????????????????????????
  • ??????????????????? Penicillium
  • ????????????????????????????????????????????????

5
?????????????????
  • ?????????? ???? ?????????????????????????????
    Fleming
  • Penicillium ???????????????????????
  • - ????????????????????????????????????????????????
    ?????
  • - ?????????????????? penicillin- bing ding
    protein PBP
  • - ???????????????? ???????????????

6
??????????????????????
  • ?????????? 6- aminopenicillanic acid (6 - APA)
  • ??????????????????????? ß-lactam ring
    ???thiazolidine ring
  • ?? acyl group ?????????????????? 6

7
????????????????
  • ??????????????????( natural penicillin)
  • - ?????????? ?? ???????????
  • - ?????????? ?? ??????????

8
???????????????????????? (semi synthetic
penicillin)
  • - ??????????
  • - ?????????????????????????
  • ???????????? ???????????????????????????? ??
  • ?????????? ?????????????????????????
  • ??????????? ???????????????? ????????

9
?????????
  • ????????????????????????????????????????????
    ?????????
  • ????????????????????????????
  • ?????????????????????????????????????????????????
  • ???????????????????????????
  • ??????????????????????????????????

10
????????
  • ???????????????????????????????????????????
  • ????????????????? ????
  • - ????????? ???? ????????
  • - ??????????

11
???????????
  • ?????? ??????? ??????
  • ???? 404652043
  • ???????????????????????????
  • ???????????????
  • ??????????????? 12
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