NovaMin

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NovaMin
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What is NovaMin?
A high-tech active ingredient used in the
most innovative professional dental products.
Material Description
Technical Breakdown

• NovaMin is a breakthrough
• remineralization technology.
• A tasteless white powder form.
• NovaMin amplifies the natural
• protective and repair mechanisms
• for teeth and gums.
• Extensively proven in clinical and
• scientific studies at leading dental
• schools around the world.

• Comprised of calcium,
• sodium, phosphorous
• and silica, all natural
• elements found in the
• body
• Chemical name is Calcium Sodium
• Phosphosilicate
• NovaMin is recognized as the only man
• made ingredient that directly leads to the
• formation of new tooth mineral
• (HCA)

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What Does NovaMin Do?
Repairs Surface Lesions Forms biomimetic HCA on
tooth dentin and enamel surface lesions
Reduces Sensitivity Occludes dentin tubules
forms a protective biomimetic HCA layer.
Improves Gingival Health Antimicrobial
properties Anti-inflammatory properties reduce
gingivitis.
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The NovaMin Solution
Hard Tissue Benefits
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The NovaMin Solution
Soft Tissue Benefits
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NovaMin How it Starts
NovaMin is also called calcium sodium
phosphosilicate. It is made from elements
naturally found in healthy teeth and bones
Calcium ( ), Phosphorus ( ), Sodium ( )
and Silicon ( )
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Step 1 pH Elevation
NovaMin reacts with saliva. Na ions release,
elevating pH into the range essential for HCA
formation.
H2O
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Step 2 Mineral Release
Ca2 and P5 ions are released, saturating saliva
with the ions needed for remineralization.
Ca2
P5
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Step 3 Bacterial Kill
Na and Ca2 ions overwhelm bacterial cells
ability to regulate their water content, leading
to lysis (cell death) of harmful bacteria in the
mouth.
F. Nucleatum
S. Mutans
-99.99
-99.999
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Step 4 Crystal Building
Demineralized lesions attract Ca2 and P5 ions,
where they build new HCA crystal to remineralize
the defect from the bottom up.
Enamel Crystal Prism
Tooth Mineral Structure - Hydroxy-carbonate
Apatite (HCA)
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Step 5 Time Release
NovaMin particles adhere to tooth surfaces for up
to 7 days, continuing to release Na, Ca2, and
P5 ions to maintain elevated pH at the tooth
surface and foster remineralization over time.
Enamel Crystal Prism
Tooth Mineral Structure - Hydroxy-carbonate
Apatite (HCA)
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Remineralization of Dentin EnamelIn-vitro
Study In-Situ Models
Exposed Dentin In-vitro
Surface Lesion In-vitro
Surface Abrasion In-Situ
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NovaMin Product Focuses

• Sensitivity
• Faster better results
• Addresses symptom, not cause.
• Gingivitis
• Faster results
• Less controversial ingredient
• Root Caries/Remineralization
• Adult caries predominantly related to
  hyposalivation.
• NovaMin directly addresses this etiology.

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NovaMin SensitivityNovaMin Therapy Paste
ResultsClinical Results Vs. Placebo
plt0.001
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NovaMin SensitivityNovaMin Therapy Paste
ResultsClinical Results Vs. Other Actives
plt0.05
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NovaMin vs. Fluoride Remineralization of Dentin
NTI-UCSF In-vitro Study Dentin Remin/Demin Model
Product Tested Code
7.5 NM/1100 ppm MFP 1
7.5 NM 2
Company CR 5000 ppm NaF 3
Company CG 1.1 ppm MFP 4
0 NM/O ppm F 5


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NovaMin and GingivitisAnti-Microbial Properties
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NovaMin and GingivitisPilot Clinical Study
Gingival Bleeding Index
plt0.01
-59
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NovaMin and GingivitisPilot Clinical Study
Plaque Index
plt0.025
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NovaMin/Fluoride Enamel Remineralization
In-vitro Study Remin/Demin Model
Surface Lesion
100µm
Sound Enamel
Sound Enamel
Sound Enamel
NovaMin Dentifrice F Treated Sample
Fluoride Dentifrice Treated Sample
Demineralized Untreated Sample
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NovaMin/Fluoride Enamel Remineralization
In-vitro Study Remin/Demin Model
plt0.001