ALCOHOL

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ALCOHOL

• Chapter 8

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PRODUCTION OF ALCOHOL

• Anaerobic condition CO2
• Glucose Pyruvate
  Acetaldehyde
• Fermentation of yeast
• 
  

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PRODUCTION OF ALCOHOL

• Acetaldehyde
• NADH
• NAD
• 
  
• Ethanol

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ENERGY CONTENT OF COMMON ALCOHOLIC BEVERAGES
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Alcohol Metabolism
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DIGESTION AND ABSORPTION OF ALCOHOL

• No digestion required
• Absorbed by simple diffusion and moves directly
  into blood stream
• No specific mechanism required to enter body
  cells
• Alcohol damages cell membrane proteins as it
  enters body cells.

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ALCOHOL METABOLISM
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ALCOHOL METABOLISM
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ALCOHOL METABOLISM
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Catalase

• Found in the liver
• Minor pathway for alcohol metabolism
• Catalase
• H2O2
  H2O
• Ethanol
  Acetaldehyde

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What to do with Acetaldehyde?

• Acetaldehyde dehydrogenase
• Acetyl CoA is non-toxic to body cells

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Fate of Acetyl-CoA

• CO2 H2O
• Acetyl-CoA Fatty Acid
• Glucose

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Moderate Alcohol Consumption Versus Alcohol Abuse

• Benefits and Problems

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Problems Associated with Alcohol Abuse

• Increases 5 of the top 10 causes of death in the
  U.S.
• Cirrhosis of the liver
• Inflammation of stomach and pancreas
• Hypertension and hemorrhagic stroke

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Problems Associated with Alcohol Abuse

• Brain damage and neurotransmitter imbalances
• Myocardial depression and Arrhythmias
• Cardiomyopathy
• Fetal Alcohol Syndrome