Chapter 14 Hallucinogenic Drugs

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Chapter 14 Hallucinogenic Drugs
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MescalinePeyote cactus
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PsilocybinPsilocybe mushrooms psilocybin ?
psilocin
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LSD
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Pharmacology of Hallucinogenic Drugs
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Pharmacology of Hallucinogenic Drugs

• LSD Trip (psychological effects)
• Onset
• Plateau
• Peak
• Come-down

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Pharmacology of Hallucinogenic Drugs

• Physiological effects
• Activate sympathetic nervous system
• Dilated pupils
• Heart rate increase
• Blood pressure increase
• Body temperature increase
• Dizziness
• Nausea and vomiting

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Pharmacology of Hallucinogenic Drugs

• Most hallucinogens are 5-HT receptor agonists
• If you use a 5-HT receptor antagonists together
  with a hallunicongen, illusions and
  hallucinations disappear

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Pharmacology of Hallucinogenic Drugs Acquisition
of an LSD/saline discrimination and attenuation
of the drug stimulus cue
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Pharmacology of Hallucinogenic Drugs Acquisition
of an LSD/saline discrimination and attenuation
of the drug stimulus cue
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Pharmacology of Hallucinogenic Drugs

• Problems with hallucinogenic drugs
• Bad Trip
• Flashbacks
• Psychotic breakdown

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Dissociative Anesthetics

• PCP

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Dissociative Anesthetics

• Ketamine crystals

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PCPSelf-administration of PCP into the nucleus
accumbens shell by rats
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KetamineKetamine administration produces a
dose-dependent increase in psychotic-like symptoms