BIPN148 Lecture 11 - PowerPoint PPT Presentation
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BIPN148 Lecture 11
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(persistently active) CaMKII. CaMKII. Ca / CaM. LTP-induced changes in AMPA currents ... Trafficking of GluR1/2/3. LTP phosphorylation of AMPA-R. GluR1 ... – PowerPoint PPT presentation
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Title: BIPN148 Lecture 11
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BIPN148 Lecture 11
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Biochemical Basis of LTP
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LTP in Thr286A mutant mice
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Transient CaMKII Activation
CaMKII
Thr 286 Autophosphorylation (persistently active)
Ca/ CaM
NMDA Receptor
CaMKII
CaMKII
NMDAR Association (persistently active)
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LTP-induced changes in AMPA currents
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Effect of CaMKII on AMPA conductance
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Glycine induces potentiation
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Glycine increases surface GluR1
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Trafficking of GluR1/2/3
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LTP phosphorylation of AMPA-R
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GluR1 phosphorylation at S831
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S831 phosphorylation on GluR1
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(No Transcript)
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LTP induces S831 phosphorylation
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(No Transcript)
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