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Bruce Lambert, PhD. Associate Professor. Pharmacy Administration and Pharmacy Practice ... Adam Scheffler, MA, LSW. Policy Researcher and Consultant. Gordy Schiff, MD ...
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... transcribed by RNA Pol II ... cleavage factor II PAP: Poly(A) polymerase CPSF PAP PABPII- poly(A) ... different from mRNA p p Pol II ctd mRNA SCAFs: ...
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Digest the labled capping substance(xp) to yield x by phosphomonoesterase,then ... II leave the complex; PAP enters .aided by CPSF initiates short poly(A) synesis. ...
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exemple de la dystrophie musculaire oculo-pharyng e (OPMD) ... stimulates PAP. controls poly(A) tail length. PABP2: AAAAA. AAAAA. PABPN1. 5' CPSF. AAAA ...
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Cleavage-and-polyadenylation specificity factor (CPSF) binds via recognition of ... Nature Structural Biology 7:838, 2000 and Barnard D.C. et al, Cell 119:641, 2004. ...
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Largest regional annual scientific conference in the country. Currently over 700 members ... Medication Safety Initiative (Funded by Michael Reese Health Trust) ...
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Regulating gene expression Goal is controlling Proteins How many? Where? How active? 8 levels (two not shown are mRNA localization & prot degradation)
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Protects mRNA from ribonucleases: mRNA's without caps rapidly ... MT binds to CE (mammals) or P-CTD (yeast) and to the terminal GpppN (mammals). c, Imp ...
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Cap 1 found in both eukaryotic and viral RNAs. Cap 2 found only in eukaryotic cells ... More variation exists in plant than in animal motif ...
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Department of Pathology, National Cheng Kung University Hospital ... Influenza viruses bind to sialic acid present on cell surface through the ...
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Finally, binding of poly(A)-binding protein II (PABII) binds to the initial ... Adapted from Textbook 'Molecular Cell Biology' Lodish H., Berk A., Zipursky L. ...
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Nucleolus. For rRNA processing. Nucleolus and other subcompartments ... Nucleolus with sub-compartments. From RNA to Protein. Protein synthesis ...
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Covers : RNA Processing Translation Genetic Engineering Membrane Transport
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Part 2 of excerpts chosen by Winfried Just from: Molecular Biology Primer Angela Brooks, Raymond Brown, Calvin Chen, Mike Daly, Hoa Dinh, Erinn Hama, Robert Hinman ...
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Title: CSE 181 Project guidelines Author: mchaisso Last modified by: bIOcOMP Created Date: 4/8/2004 10:16:51 PM Document presentation format: Presentazione su schermo ...
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Title: CSE 181 Project guidelines Author: mchaisso Last modified by: bIOcOMP Created Date: 4/8/2004 10:16:51 PM Document presentation format: Presentazione su schermo ...
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... fresh-from-the-garden. Flavorful. Progresso's Brand Report ... Newspapers: We will use free-standing inserts in newspapers and issue coupons to induce trial. ...
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Mechanisms of Transcription RNA polymerase does not need a primer to initiate transcription. The RNA product does not remain base-paired to the template DNA strand.
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a more accurate outline of the events involved in genome expression, especially ... duquel se trouvent deux ions Mg 2 qui indiquent l 'emplacement du site actif. ...
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From chromosome to gene. Eukaryotes contain a nucleus in which the ... DNA can bend and kink. nucleosome. DNA. 10 nm fiber. 30 nm fiber. Protein matrix ...
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Elena G. Strekalova, BU. Giancarlo Franzese, Universitat de Barcelona ... Exp. data from R.J. Speedy and C.A. Angell, (1976) P. LG spinodal. C. C' Widom line. T ...
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Activation of gene structure. Initiation of transcription. Processing transcript ... Stability of Eukaryotic mRNA. Both the 5' and 3' ends of mRNA are modifed ...
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Case study, near misses. Aggregate data. Nature of event reporting ... Data mining, fuzzy matching. Use by multiple players at the same time. Audit trail ...
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These GEFs rapidly cycle between cytosolic and membrane-bound forms ... One example of interference with the mRNA export pathway is viral-host ...
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Title: PowerPoint Author: win Last modified by: user_mother Created Date: 9/24/2001 9:26:49 AM Document presentation format:
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Hfr bacteria possess F factor integrated into the bacterial genome. ... Human genome project. Animal biotechnology. Plant biotechnology ...
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How cells read the genome: from DNA to protein
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Formation of mature eukaryotic mRNA from pre-mRNA ... forms 5'-2' bond with A in the branch-point sequence to form an RNA lariat ...
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Controlling the rate at which the mRNA decays can regulate the levels of ... (dsRNA) introduced into the nematode worm, C. elegans, and is largely conserved ...
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22.3 Splice junctions are read in pairs. 22.4 Nuclear splicing proceeds through a lariat ... Photograph kindly provided by Bert O'Malley. ...
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Molecular Biology Primer
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An insight into basic cellular and molecular biology mechanisms ... or integrated into host genome (potential oncogenesis and/or latent infection) ...
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Add a cap and a polyA tail to mRNA. Add a methyl group to 2'-OH of ribose in mRNA and rRNA ... Ligation of the ends (with ATP hydrolysis) ...
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Terminology (structure): intron, exon, 5' regulatory region, ribosomal RNA, ... transcription start site. TFIID binds to TATA box via TATA-binding protein (TBP) ...
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Differentiate between messenger RNA, small nuclear RNA, ribosomal RNA, and ... Cajal bodies. GEMS (Gemini of coiled-bodies) Interchromatin granule structures ...
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Molecular Biology Primer
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I n t e g r i t y - S e r v i c e - E x c e l l e n c e ... Disjointed operation in 3 separate facilities. with temporary use of building 950 in 'clear zone' ...
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1. Capping at the 5'-end. 2. Polyadenylation at the 3'-end ... The cap serves several functions, including protection of the mRNA from ...
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Chap. 8 Post-transcriptional Gene Control Topics Processing of Eukaryotic Pre-mRNA Regulation of Pre-mRNA Processing Cytoplasmic Mechanisms of Post-transcriptional ...
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Gene Annotation (cooperative ... Watson & Crick with DNA model Rosalind Franklin with X-ray image of DNA DNA: ... Major events in the history of Molecular Biology ...
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Require General Txn Factors (or GTFs) Txn in chromatin/nucleosomes complex ... an excess of nonspecific sites to adsorb proteins in crude lysates that will ...
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RNA pol performs essentially the same reaction in all cells,from bacteria ... strength of a promoter,we mean how many transcripts it initiates in a given time. ...
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How Do Individuals of a Species Differ? Why Bioinformatics? ... Chromosomes = bookshelves. Genes = books ... Cell Information: Instruction book of Life ...
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TBP in TFIID binds to the TATA box. TFIIA and TFIIB are recruited with ... A:T base pairs (TATA box) are favored because they are more readily distorted to ...
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DNA-binding regulatory proteins. chromatin-modifying enzymes. Why? ... polymerase is associated with a new set of protein factors required for ...
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Enhances nuclear export. Enhances mRNA tln. RNApII transcript processing. mRNA structure ... Exonic Splicing Enhancer (ESE) sequences ...
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De nouveaux savoirs pour le Canada du 21e si cle/Creating New Knowledge to better meet ... Postes double affectation? Faudra-t-il embaucher des charg s de ...
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Decorating the Gallery: Improving the Properties of Cobalt Hydroxide by Anion ... reserve a day, or at least an afternoon, to your scholarship (no meetings, no ...
Tailor to your audience. Use your contacts. Talking points are helpful. Ask for assistance ... Make sure the cycle of application and award suits your plans ...
