Mmae PowerPoint PPT Presentations

MINIATURE ENGINEERING SYSTEMS GROUP (http://www.mmae.ucf.edu/~kmkv/mini) Two-Stage CryoCooler Development for Liquid Hydrogen Systems

Su-DHL-5. SuDHL-6. Toledo. WSU-DLCL-2. IC50_free-DM1, nM. WSU-NHL. Surface Receptor. IC50_DM1 (ng/mL) IC50_free-MMAE, nM. IC50_MMAF (ng/mL) Pfeiffer. Anti-CD79b DM1 ...

Antibodies and small molecules in ADCs are covalently linked through a linker that allows small molecule drugs to bind to the lysine side chain amino groups in the antibody, such as T-DM1, or to sulfhydryl groups obtained by reduction of disulfide bonds between antibody chains, such as an anti-CD30 IgGl monoclonal antibody cAClO-MMAE conjugate or to an engineered cysteine residue introduced at a particular site on the antibody, such as a THIOMAB-drug conjugate. The number of small molecules in the ADC and the location of the connections can be inconsistent through the first two forms, and the ADC is actually a mixture.

Recently, the FDA awarded the patent-based enfortumab vedotin antibody-conjugated drug developed jointly by Seattle Genetics and its partner Astellas. The drug is currently in a phase II study of a key metastatic transitional cell carcinoma. This is undoubtedly a good news for Seattle Genetics. They have also marked the project with a "breakthrough therapy" label. After the first commercial product, Adcetris, this is the company's most promising ADC drug. Enfortumab vedotin consists of an anti-Nectin-4 monoclonal antibody and Seattle's own synthetic cytotoxin monomethyl auristatin E (MMAE), which is the first ADC drug to target solid tumor Nectin-4, targeting bladder cancer.

Lymphoma is a cancer that develops in the lymphatic system and is mainly divided into two types of Hodgkin's lymphoma and non-Hodgkin's lymphoma. And there are large, abnormal lymphocytes, Reed-Sternberg cells, in their lymph nodes of most patients with Hodgkin's lymphoma. As long as the intervention is early enough, these patients can often achieve long-term relief.

Intratumoral heterogeneity is one of the key reasons that lead to the failure of anticancer therapy and death of patients and is also an important issue that researchers are trying to solve. Learn more about ADC at https://www.creative-biolabs.com/resource/adc/pdf/com/downloads/HER2-ADC-preparation-and-potency-evaluation-Creative-Biolabs.pdf

Avon Lifesciences (Avon Organics) is a pharmaceutical company aligned across two business verticals viz. Products and Services, incorporated in August 1993. Ajit Kamath is the Executive Chairman and Managing Director of Avon Lifesciences.

The enfortumab vedotin brought by Seattle Genetics and Astellas is expected to bring a good news to bladder cancer patients. This is an antibody drug conjugate (ADC) under development. Learn more about ADC at https://www.creative-biolabs.com/resource/adc/pdf/com/downloads/HER2-ADC-preparation-and-potency-evaluation-Creative-Biolabs.pdf

Dr. Paul Zarda is a well-qualified professional who has served many prestigious positions in his career. Currently, he is serving as a Distinguished Member, Technical Staff, and Manager of the Engineering Methods Group at Lockheed Martin Missiles and Fire Control.

Dr. Paul Zarda is the Manager at Engineering Methods Group, Lockheed Martin Missiles and Fire Control, Orlando, Fl. He is also an Adjunct Professor at UCF, where he holds the title of Research Professor of Mechanical Engineering in the Dept. of Mechanical, Materials and Aerospace Engineering.

Dr. Paul Zarda is the Manager at Engineering Methods Group, Lockheed Martin Missiles and Fire Control, Orlando, Fl. His role involves helping provide direct support of the engineering community in the areas of Mechanical Design and Analysis, System’s Engineering, & Optical Design.

Design of optimum procedures for deciding between ... The model has the following components: Parameter Space (for parametric ... by Johnson, Dudgeon. ...

The measurement provides quaternion data on the current sensor position (meaning ... The quaternion filter predicts and corrects the state vector each time a ...

Title: IIT s International Initiative Author: Edward Schaefer Last modified by: Paloma Vivas Created Date: 9/8/2000 8:48:52 PM Document presentation format

Blinds. Pros. Block Solar Radiation. Doesn't obstruct view. Cons ... Further test involving glazing, blinds and awnings. Material for the awning. Our Thanks...

Consiliul Na ional al ntreprinderilor Private Mici i Mijlocii din Rom nia CNIPMMR - S-IMM-T Crearea unui Centru regional de Servicii pentru promovarea ocup rii ...

Probabilistic Weather Forecasting Using Bayesian Model Averaging J. McLean Sloughter Adviser: Tilmann Gneiting GSR: Susan Joslyn Committee members: Adrian Raftery ...

Lucent Technologies Samsung Telecom. General Motors Western Electric. CTA Xerox . Transcripts of completion of 4 years certified in native language & in english ...

SEGUROS PARA INSTALACIONES CON HIDROCARBUROS DE PETR LEO Ing. Jorge E. MANGOSIO Secretar a de Energ a

B-cell neoplasm characterized by sparse malignant cells in an inflammatory ... SGN-40 induced dose-dependent lysis via antibody-dependent cellular cytotoxicity ...

Effect of Niobium Additions on

Pr sentation par: Dr. Vanita Misquita Ph.D. Director of Overseas Programs iitparis@aol.com misquita@iit.edu http://iitparis.free.fr Graph *

MicrostructureBased Kinetic Model of Austenitization of Steels

Predict microstructure and properties after an arbitrary thermal cycle ... Dr. Philip Nash Dr. Calvin Tszeng. Learning and experimental resources ...

Identify the items typically present on a syllabus ... Dr. Steven R. Greenberg, 135 Hart Hall. Bridgewater State College, Bridgewater, MA 02325 ...

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MINIATURE ENGINEERING SYSTEMS GROUP Two-Stage CryoCooler Development for Liquid Hydrogen Systems This work is supported by NASA Hydrogen Research at Florida Universities.

Title: Core Loss of A Test Inductor Author: Liping Last modified by: Krishna Created Date: 5/22/2003 1:26:34 PM Document presentation format: On-screen Show

The Design of High-Speed High-Power Density Machines Liping Zheng Tasks Design two kinds of motors (1kW and 3kW) using sizing equations combined with FEM simulation ...

TiN and MoS2 bilayer coatings will be deposited on a glass substrate Testing of the above film will be carried out for satisfying requirements of good wear ...

... DLC coatings will be prepared and characterized. Characterization of bilayer coatings of TiN and MoS2 on a silicon wafer is being carried out.

MINIATURE ENGINEERING SYSTEMS GROUP Two-Stage CryoCooler Development for Liquid Hydrogen Systems Miniature Engineering Systems Group Core Group of Faculty Outline of ...

Great Navel Orange Race Project (Competition and Report) = 25 ... Great Navel Orange Race (4/6) MATLAB/Final Report Due. COMPETITION. NO LECTURE. 4/2 - 4/6 ...

ASME-UCF member. UCF Dues: $15 (cash or check only! ... return to an officer or drop off at ASME office EGN1 148 during office hours. ...

Upcoming Events. Next Meeting September 31st. Details coming soon. Industry Tours. Wheeled Coach ... Upcoming Events. 8. HELP WANTED! Student Design Competition ...