Oasis of Hope

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Oasis of Hope

• A 45-year tradition of
• Body, mind, spirit medicine

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Oasis Background
Founder Dr. Ernesto Contreras, Sr.

• My grandfather (my mothers father)

• Rebels stole everything from family during
  childhood

• Father died from alcoholism

• Mother, state school teacher, 5 kids

• Contreras gets in military medical school in
  Mexico City, graduates 1939

• Sent by military to Tijuana in 1955

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Oasis Background
The Conception of Oasis of Hope

• 1963, Mrs. Contreras opens home to hospitalize
  patients (children stay at neighbors homes)

• 1965, Trip around the world

• Pergamum, Ancient Healing Center

• 3 sections Emotional healing, spiritual healing,
  physical healing

• Contreras realizes the deficiency in 20th century
  medicine

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Oasis Background
The Birth of Oasis of Hope Hospital

• Contreras proposes that doctors must form
  friendships with patients for healing to take
  place.

• Contreras criticized

• Contreras commits to minister to the whole
  person Body, Mind and Spirit

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Oasis of Hope Approach
Founding Principles
1. JESUS CHRIST IS OUR MEDICAL DIRECTOR
2. DO THE BODY NO HARM
3. LOVE YOUR PATIENT AS YOURSELF
4. DO THE POSSIBLE TRUST GOD TO DO THE
IMPOSSIBLE

• HOLY SPIRIT WELCOME TO WORK WITHOUT RESTRAINT

6. ALL THE GLORY BELONGS TO GOD.
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Oasis of Hope Approach
Physical Therapies

• Explore all options supported by science
• Integrate conventional and natural therapies
• Minimize negative side effects
• Educate and empower patient
• Follow-up and support patient

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Oasis of Hope Approach
Emotional Support

• Paradigm shift Dying from to living with
• Patch Adams, The death in life
• Education Positive Emotions Heal, Negative
  Emotions Destroy
• Support
• Practical techniques relaxation, breathing,
  laughter therapy
• Build support network

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Oasis of Hope Approach
Spiritual Support

• Build Faith
• Diminish guilt
• Devotions
• Singing/Worship
• Find purpose meaning
• Identify series of miracles
• Fellowship and pray with others

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True Healing
True Healing
The body is temporary the spirit is eternal
Donald Factor Family restoration

• William Doesnt require God to heal

Jose 30 year-old healedbus!!!
Bruce Northey
Mother of a 2-year-old girl
Father of 6-year-old boy
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Healing Fron God
True Healing

• Live life to fullest
• Do not look at circumstances
• Find meaning and purpose in all things
• You are valid

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Cancer Prayer Network
Web Pages
More Information
www.cancerprayernetwork.org
www.oasisofhope.com
Project Oasis
www.danielkennedy.info
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Integrative Regulatory Therapy
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CONVENCIONAL THERAPY

• Surgery
• Chemo Tx
• Radiation

• Immuno-
• suppressive
• Mutagenic

The Target is the Tumor

• Vicious
• Cycle
• Remission
• Relaps

Successful Failures

• Side
• Effects

• P/N/V
• Organs

• Poor
• Quality
• of Life
• High
• Mortality

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• PHILOSOPHY
• HOLISTIC
• ECLECTIC
• OASIS OF HOPE

• Tumor Vs. Patient
• Tumor Load Vs. Longevity
• Primary Tumor vs. Mets.

• PRIMUM EST NIL NOCERE
• LOVE YOUR PATIENT AS YOU LOVE YOURSELF

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Oasis Of Hope TherapiesIntegrative
Complementary
Successful Failures

• Surgery
• Chemo Tx
• Radiation

• QUALITY
• OF LIFE
• LONGEVITY

• Immuno-
• supresive
• Mutagenic

The Target Is the Patient

• Prolonged
• Remissions
• Tumor
• Stability

• Vicious
• Cycle
• Remissions
• Relapses

• Min. Side
• Effects
• Well
• Tolerated

• Side
• Effects

• Immuno-
• Stimulant
• Anti-
• Mutagenic
• Low
• Toxicity

• P/N/V
• Organs

• Poor
• Quality
• of Life
• High
• Mortality

Integrative Regulatory Therapy IRT
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IRTRegulate Cellular Metabolism

• Cancer Proliferation
• Angiogenesis
• Invasive Activity
• Undetermined lifespan

• Signaling Pathways
• Control biochemical activity of proteins and
  other cellular elements
• Directs cellular metabolism to a specific task
• Gene Dependent
• Nutrients are the most important triggers
• Derailment can be triggered by a vast array of
  substances
• Any interference modifies response

Bhalla US. The chemical organization of
signaling interactions. Bioinformatics 2002.
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IRT Signaling Transduction Nutrients That
Modify Signaling Pathways

• Downregulate or impair some overexpressed
  cellular signaling pathways that promote cancer
  progression
• Target same cellular signaling pathways as many
  chemo agents
• Non-toxic

• Cancer Proliferation
• Angiogenesis
• Invasive Activity
• Undetermined lifespan

Sarkar FH, Li Y. Cell signaling pathways altered
by natural chemopreventive agents. Mutat Res 2004
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IRT Signaling Transduction Nutrients That
Modify Signaling Pathways

• Treatment of breast cell cultures with n-3 fatty
  acids (EPA or DHA) results in increased
  expression of suppressor genes for BRCA1 and BRCA2

Bernard-Gallon DJ, et al. Differential effects
of n-3 and n-6 polyunsaturated fatty acids on
BRCA1 and BRCA2 gene expression in breast cell
lines. Br J Nutr 2002
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IRT Signaling Transduction Nutrients That
Modify Signaling Pathways

• GSE at high doses has significant in vivo
  anticancer efficacy
• Antiproliferative
• inhibited tumor growth by 57-93,
• Proapoptotic
• increased apoptotic index by 3-4 fold
• Antiangiogenic
• inhibited Vasc. Endoth. Growth Factor 47-70.

Singh RP, et al. Grape seed extract inhibits
advanced human prostate tumor growth and
angiogenesis and upregulates insulin-like growth
factor binding protein-3. Int J Cancer 2004
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IRT Signaling Transduction Nutrients That
Modify Signaling Pathways

• Proanthocyanidins Bioflavonoids
• anti-carcinogenic
• anti-inflammatory
• anti-arthritic
• anti-allergic

Bagchi D, et al. Protective effects of grape
seed proanthocyanidinsand lipid peroxidation,
DNA fragmentation...macrophage activation in
mice. General Pharmacol 1998
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IRT Signaling Transduction Nutrients That
Modify Signaling Pathways

• Green Teaepigallocatechin-3-gallate (EGCG)
• Inhibits COX-2 without affecting COX-1 expression
  at mRNA and protein levels
• Induction of apoptosis
• Cell cycle arrest
• Regulation of cell cycle-related proteins

Hussain et al. Green tea constituent
epigallocatechin-3-gallate selectively inhibits
COX-2 without affecting COX-1 expression in human
prostate carcinoma cells. Int J Cancer 2004
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IRT Oxidative Pre-conditioning Redux Regulation

• Tea catechins and polyphenols
• Radical and oxidant scavenging of reactive oxygen
  and nitrogen species
• Metal chelation of metal ions preventing
  redox-catalyzing free radicals
• Inhibition of redox-sensitive transcription
  factors

Surh YJ, et al. Molecular mechanisms
ofphytochemicals down-regulation of COX-2 and
iNOS through suppression of NF-kappa B
activation. Mutat Res 2001
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IRT Immune-stimulation

• 200 studies reviewed cancer and fruit and
  vegetable intake.
• A statistically significant protective effect for
  most cancers
• People who consumed small amounts had about twice
  the risk of cancer compared to those who consumed
  high amounts

Block G, et al. Fruit, vegetables, and cancer
prevention a review of the epidemiological
evidence. Nutr Cancer 1992.
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Nurses Health Study
IRT Immune-stimulation

• High intake of cruciferous vegetables associated
  with a 33 lower risk of non-Hodgkins lymphoma
• servings per week 5 or more vs 1 or less
• One sprout contains as much sulforophane as a
  full-grown broccoli plant

Zhang SM, et al. Intakes of fruits, vegetables,
and related nutrients and the risk of
non-Hodgkins lymphoma... Cancer Epidemiol
Biomarkers Prev 2000
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IRT Anti-Tumor Agents

• Alternative
• Nutrients Fitochemicals
• Necrosis
• Apoptosis
• Weakening

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IRT NATURAL Anti-Tumor Agents

• Oxidative DNA damage was reduced significantly
• Leukocyte oxidative DNA damage was reduced
  significantly
• Apoptotic index was 3-4 fold higher

• 50 reduction in rates of death from cancer in US
  elderly population

Prostate Tissue Before After Intervention
Agarwal S and Rao AV. Tomato lycopene and its
role in human health and chronic disease. CMAJ
2000. Franceshi S, et. Al. Tomatoes and the
risk of digestive-tract cancers. Int J Cancer
1994
Chen L, et al. Oxidative DNA damage in prostate
cancer patients consuming tomato sauce-based
entrees as a whole-food intervention.
J Natl Cancer Inst 2001
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IRT NATURAL Anti-Tumor Agents
Curcumin

• Significant therapeutic results have been
  observed in cancer patients receiving curcumin
• popular culinary spice used to flavor and color
  curries, mustards, cheese and butter

Sharma RA, et al. Phase 1 clinical trial of oral
curcumin biomarkers of systemic activity and
compliance. Clin Cancer Res 2004
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IRT NATURAL Anti-Tumor Agents

• Antioxidant.
• Inhibits lipid peroxidation
• Inhibits free radical generation
• Scavenging properties
• Protects cell membranes and DNA

• Anti-inflammatory.
• Non-steroidal anti-inflammatory agent
• Inhibiting COX-2

• Anticarcinogenic agent.
• inhibiting angiogenesis
• Suppressing proliferation of tumor cells
• Inducing apoptosis (programmed cell death) of
  cancer cells

Curcumin
Ruby AJ, et. al. Anti-tumor and antioxidant
activity of natural curcuminoids. Cancer Lett
1995.
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IRT CONVENTIONAL Anti-Tumor Agents

• Chemo RT
• Better tolerance
• Immune-protection
• Reduced resistance
• Potentialises antitumor effect
• Conventional Doses
• Metronomic Doses

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• Patient ML Age 51 Dx
  Breast CA

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PacienteTH Edad 46 Dx Ca Mama
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• Patient ST Age 70 Dx Squamous
  Cell CA

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• Patient JL Age 62 Dx
  Ovarian CA

March/31/2005
June/29/2005
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Integrative Regulatory Therapy
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IRT-C Protocol
Oxygen Boost
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H2O2
O2
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SMALL PARTICLE SIZE
LARGE SURFACE AREA
S 847 m²
S 60 m²
.07 m
7.8 m
100 ml
100 ml
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H2O2
O2