Labonachip

1
Lab-on-a-chip
powered bydigital microfluidics
Just announced
Advanced Liquid Logic, Inc. 615 Davis Drive,
Suite 800 PO Box 14025 Research Triangle Park, NC
27709 [phone] visit us by the web
at http//www.liquid-logic.com
2
Digital Microfluidics concept

• Perform basic operations using discrete units of
  liquid (i.e. droplets)
• Basic instruction set dispense, transport,
  merge, split
• Programmably assemble basic operations into
  complex fluid-handling protocols
• Combine with appropriate biochemistry, heaters,
  magnets, detectors, etc to implement
  sophisticated assays on-chip

3
The Enabling Technology - Droplet-Based Digital
Microfluidics
How It Works Electrowetting
4
Droplet Operations
Loading/dispensing
5
Droplet Operations
Transport
6
Droplet Operations
Mixing
7
Digital Microfluidics Advantages

• Discrete, programmable, software-driven,
  independent electronic control of each droplet
• No moving parts, tubes, pumps or valves
• Small, reliable, low cost equipment
• Very precise droplet volumes CV 1
• Development cycles are short, and assays can be
  tuned with software changes
• Low cost, production-ready lab-on-a-chip using
  printed circuit board technology

8
Current Development Status
Bench top research instrument in development for
release in 2008
9
Summary

• Digital microfluidics is fundamentally
  different approach to lab-on-a-chip
• A growing portfolio of operations and protocols
  is under development
• Productization is underway