Fab region

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Fab region
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VL
VH
Complex pulled apart to see complementary
surfaces
Flu antigen
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?-Lysozyme
? -Sm part of ssDNA
? -Peptide from flu ag
? -phosphocholine
Binding sites for small moleculars are deep
pockets where as for larger proteins are flatter
and undulating.
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HIV Protease in its Ab binding pocket
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Unbound Antibody
Antibody bound to antigen
Conformational Change upon binding Ag
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Fig. 4-10 Side-view of Angiotensin II bound to
Fab.
Van der Waals surface contacts
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SC 5 Ig Like domains S-S_ to Fc
receptor Proteolytically cleaved
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Toxins and their use to prepare immunotoxins
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