Overview of the immune system

1
Overview of the immune system
If you view these slides as notes pages, youll
see some questions to help you make connections
amongst all the various topics covered during the
basics of immunology lectures.
2
Immune response to damage

• Dependent on what, where and how bad
• Phased response with critical timing
• Requires chemokine signalling, receptor binding,
  etc

3
Factors influencing immunogenicity
4
Development of the immune system
5
Lymphocyte recirculation

• Lymphocytes enter 2 lymphoid organs via high
  endothelial venules (HEVs)
• Ag is transported to lymph nodes via APC
• Upon activation, lymphocytes travel to tissues

6
Important aspects of MHC

• How do peptides get into MHC groove?
• Class I peptides in cytosol associate with MHC
• Class II peptides from within vesicles associate
  with MHC

7
Central role of Th cells

• Type of immune response
• B activation or CTL generation
• Proliferation of effector cells
• Enhance functional activities of other cells