Informatics Pilot Projects

1
Informatics Pilot Projects Elaine Collier,
M.D. National Center for Research Resources
February 12, 2009
2
Informatics Pilot Projects

• NIH Roadmap for Reengineering Clinical Research
• Informatics - key component of this effort
• National effort to assist researchers involved in
  clinical and translational research
• Clinical and Translational Science Awards a
  testbed for development and adoption
• Expansion potential for researchers at other
  institutions

3
Informatics Pilot Projects

• Focus on data collection, management, sharing
  tools/solutions for investigators of small and
  medium size studies
• Software must be available for all adoption
• RFP issued February 2008
• Proposals received April 2008
• Evaluation summer 2008
• Awarded Fall 2008

4
I2B2 Repository Federated Sharing

• Build on i2b2 software architecture to support
  multi-institutional querying of large data sets
• Hypothesis generation and research design using
  anonymized data
• Governance and Evaluation are key phases
• University of Washington University of
  California, Davis University of California, San
  Francisco Harvard University Recombinant Data
  Systems
• Nicholas Anderson, Principal Investigator

5
REDCap (Research Electronic Data Capture)

• Tool for data collection, management, and
  analysis to be expanded and enhanced
• Enhancements will facilitate sharing among
  investigators and across institutions
• Incorporate standards, sharing of templates/case
  report forms, novel data collection tools
• Widely used at multiple institutions already
• Vanderbilt University, Mayo Clinic, and Oregon
  Health and Sciences University
• Paul Harris, Principal Investigator

6
PHYSIO-MIMI

• Research Integration of Diverse Types of Data
• complex signaling, clinical, genetic, imaging
  data
• Will allow secure, safe and regulated transfer of
  information from clinical care systems and
  research databases
• Sleep research, which requires diverse data, will
  be model
• Case Western Reserve University of Michigan
  Marshfield Clinic University of Wisconsin at
  Madison
• Susan Redline and GQ Zhang, Co-Principal
  Investigators