Hemorrhagic Fever Virus

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Hemorrhagic Fever Virus
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Hemorrhagic Fever Virus

• A group of viruses which are transmitted by
  rodents or arthropods cause viral hemorrhagic
  fever.

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Hemorrhagic Fever Virus

• Bunyaviridae family
• Hantavirus
• Crimean-Congo hemorrhagic fever virus (CCHFV)
• (OR Xinjiang hemorrhagic fever virus, XHFV)
• Flaviviridae Family
• Dengue virus

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Hantavirus

• HFRS
• (hemorrhagic fever with renal syndrome)
• HPS
• (hantavirus pulmonary syndrome)

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Biological Properties

• spherical, oval, polymorphic
• 120nm in diameter on average
• envelope
• -ssRNA, 3 segments

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Pathogenicity

• source rodents, especially rats
• transmission route
• respiratory tract
• gastrointestinal tract
• contact direct contact, bite
• vertical route
• arthropod transmission

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Pathogenicity

• Pathogenesis
• damage of small blood vessels
• different in the major organs

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Pathogenicity

• Clinical Findings
• HFRS
• typical symptoms fever, hemorrhage, kidney
  damage
• HPS
• Early symptoms fatigue, fever and muscle aches
• Late symptoms coughing and shortness of breath,
  lungs fill with fluid.

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Dengue virus
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hantavirus