Sexually Transmitted Diseases

1
Sexually Transmitted Diseases
Information to help you when you study for boards
Kristine Krafts, M.D.
2
Sexually Transmitted Diseases

• Syphilis
• Gonorrhea
• Non-gonococcal urethritis/cervicitis
• Herpes
• Human papillomavirus

3
Sexually Transmitted Diseases

• 15 million cases per year worldwide
• Most in 15-24 year olds
• 5 of the top 10 infectious diseases requiring
  notification are STDs chlamydia, gonorrhea,
  AIDS, syphilis, hepatitis B
• In US top 2 STDs are herpes and HPV

4
Syphilis

• Caused by Treponema pallidum
• 33,000 cases/year
• Primary painless chancre
• Secondary rash, lymphadenopathy
• Tertiary proximal aortitis, brain lesions

5
Syphilitic plaques
6
Syphilitic ulceration
7
Syphilitic chancre
8
Syphilitic rash
9
Condylomata lata
10
Gonorrhea

• Caused by Neisseria gonorrhoeae
• 300,000 cases/year
• Males severe, purulent urethritis (can spread to
  prostate, testis)
• Females cervicitis (can spread to tubes,
  ovaries)
• Can be transmitted during birth

11
Gonorrhea
12
Non-Gonococcal Urethritis and Cervicitis

• Caused by Chlamydia (mostly) and other bugs
• Chlamydia 900,000 cases/year
• Symptoms indistinguishable from gonorrhea
• Reiter syndrome
• Occurs mostly in people who are HLA-B27
• Urethritis, arthritis, conjunctivitis,
  mucocutaneous lesions

13
(No Transcript)
14
Genital Herpes Simplex

• 50 million affected people in US
• Most cases caused by HSV-2 (HSV-1 more oral)
• Painful, erythematous vesicles on genital
  skin/mucosa
• Primary lesions plus lymphadenopathy, fever
• Recurrences milder, shorter
• May be fatal in immunocompromised patients and in
  neonates

15
Human Papillomavirus

• Causes squamous proliferations in genital tract
• condylomata acuminata (venereal warts)
• precancerous lesions
• carcinomas
• Condylomata HPV 6, 11
• Carcinomas HPV 16, 18, others

16
Condylomata acuminata
17
Condylomata acuminata
18
Condylomata acuminata cervix